ArticleWorld journal of gastroenterology2024
Pathophysiology of severe gallstone pancreatitis: A new paradigm.
Article in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Age-related vulnerability and clinical outcomes in acute pancreatitis: a stratified cohort study of 1,034 patients.BMC gastroenterology · 2026Article
- Analysis of the association between the neutrophil-to-lymphocyte ratio (NLR) and liver injury complicating acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Impact of periampullary diverticulum on the incidence of post-endoscopic retrograde cholangiography pancreatitis.World journal of gastrointestinal endoscopy · 2025Article
- Acute cholangitis due to common bile duct stones: Clinical outcomes in patients with and without concurrent acute pancreatitis.World journal of clinical cases · 2025Article
- Post-Cholecystectomy Pancreatitis When Zero Means Lethal: Fulminant Post-Cholecystectomy Pancreatitis Following a Benign Initial Ranson Score-A Case Report.Clinical case reports · 2025Article
- Spontaneous Unusual Backflow from Duodenum to Biliary System in a Dog with Pancreatic Abscesses: A Case Study.Animals : an open access journal from MDPI · 2025Article
- The role of tRNA-Derived small RNAs (tsRNAs) in pancreatic cancer and acute pancreatitis.Non-coding RNA research · 2025Review
- Valproate sodium-associated acute pancreatitis: a case report and systematic analysis of antiepileptic drug adverse events in FAERS.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic type), in which hepatobiliary and pancreatic lesion severity is inversely related to the presence or absence of impacted ampullary stones. Severe GSP is caused by stones that are persistently impacted at the ampulla with biliopancreatic obstruction (biliary type), and probably, stones that are either temporarily lodged at the duodenal orifice or passed into the duodenum, thereby permitting reflux of bile or possible duodenal contents into the pancreas (pancreas type). When the status of the stones and the presence or absence of impacted ampullary stones with biliopancreatic obstruction are determined, the clinical course and outcome can be predicted. Gallstones represent the main cause of acute pancreatitis globally, and clinicians are expected to encounter GSP more often. Awareness of the etiology and pathogenesis of severe disease is mandatory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.