ReviewPhysiological reviews2024
Physiological basis for xenotransplantation from genetically modified pigs to humans.
Review in Physiological reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Multiple genetic engineering of porcine red blood cells improves compatibility with human blood.iScience · 2026Article
- Pig Matrix: a matched multiomics 3D regulatory genomics database for evolutionary and comparative analyses in pigs.Molecular biology and evolution · 2026Article
- Bioprinting and assembly of organ building blocks for tissue engineering applications.Materials today. Bio · 2026Article
- Stromal-Derived Factor-1 (SDF-1/CXCL12) and Skin Wound Healing Research at the Intersection Between Regenerative Biology and Medicine.International journal of molecular sciences · 2026Review
- Modern xenotransplantation: rewiring glycan-mediated immunogenicity via genome-glycome convergence.EBioMedicine · 2026Review
- Review
- The use of transgenic animals for xenotransplantation: An update.Animal models and experimental medicine · 2025Review
- Recent progress in xenotransplantation and its application to pediatric kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Review
- Pluripotent stem cell-based approaches for heart repair and the potential of genetic modifications.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Physiologic Homeostasis in a Living Human after Pig Kidney Xenotransplantation.Nature communications · 2025Article
- Current status and prospects of genetically modified porcine-to-human cardiac xenotransplantation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Review
- Article
- Immune cell landscape in a human decedent receiving a pig liver xenograft.Nature medicine · 2025Article
- Scientific advances in the assessment, modification, and generation of transplantable organs for patients with end-stage organ diseases.Lancet (London, England) · 2025Review
- Pediatric partial heart xenotransplantation as an early use case of xenograft tissue.Future cardiology · 2025Review
- Review
- The draft genome of the Wisconsin Miniature SwineTM, a valuable biomedical research tool.G3 (Bethesda, Md.) · 2025Article
- Genetically Modified Animal-Derived Products: From Regulations to Applications.Animals : an open access journal from MDPI · 2025Review
- Review
- [Research and application progress for liver xenotransplantation].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome formidable immunological and physiological barriers in pig-to-nonhuman primate (NHP) xenotransplantation and achieved prolonged pig xenograft survival. These studies informed the design of Revivicor's (Revivicor Inc, Blacksburg, VA) genetically engineered pigs with 10 genetic modifications (10 GE) (including the inactivation of 4 endogenous porcine genes and insertion of 6 human transgenes), whose hearts and kidneys have now been studied in preclinical human xenotransplantation models with brain-dead recipients. Additionally, the first two clinical cases of pig-to-human heart xenotransplantation were recently performed with hearts from this 10 GE pig at the University of Maryland. Although this review focuses on xenotransplantation of hearts and kidneys, multiple organs, tissues, and cell types from genetically engineered pigs will provide much-needed therapeutic interventions in the future.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.