Observational studyThe Journal of international medical research2024
Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study.
Observational study in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparative Analysis of Novel Inflammatory and Nutritional Indices (m-HALP, HALP, SII, SIRI) for Risk Stratification in Septic Patients: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Systemic Inflammatory Response Index (SIRI) Among Patients With Sepsis: A Retrospective Observational Study.Cureus · 2026Article
- Short-term outcome and prognostic factors in acute fulminant myocarditis with acute kidney injury patients.Frontiers in medicine · 2026Article
- The association between the systemic inflammation response index and overactive bladder: a cross-sectional study.European journal of medical research · 2025Article
- Early detection of central line-associated bloodstream infection in intensive care unit patients using the systemic inflammatory response index (SIRI).GMS hygiene and infection control · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI).
methodsIn this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan-Meier survival curves. Various Cox proportional hazards regression models were developed to determine the association between the SIRI and mortality in patients with SA-AKI. Subgroup analyses were also performed to explore the association between different SIRI tertiles and all-cause mortality.
resultsAfter adjusting for several confounders, the second SIRI tertile (2.5 < SIRI < 7.6) was found to be an independent risk factor for 30-day mortality [hazard ratio (95% confidence interval): 1.19 (1.01-1.40)], 90-day mortality [1.22 (1.06-1.41)], and 365-day mortality [1.24 (1.09-1.40)]. Furthermore, high SIRI values were associated with increased risks of 30-day, 90-day, and 365-day mortality in patients with SA-AKI across all three models. The third tertile showed a significant association with adverse outcomes in most subgroups.
conclusionsThe SIRI serves as a comprehensive biomarker for predicting all-cause mortality of critically ill patients with SA-AKI.
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