Evidence map›Paper›PMID 38520523›Full record

SynthesisEuropean journal of nutrition2024

Associations of soy product intake with all-cause, cardiovascular disease and cancer mortality: Guangzhou Biobank Cohort Study and updated meta-analyses.

Ting Yu Lu, Wei Sen Zhang, Chao Qiang Jiang, Ya Li Jin, Shiu Lun Au Yeung, Kar Keung Cheng, Tai Hing Lam, Lin Xu

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting Yu LuSchool of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.
Wei Sen ZhangGuangzhou Twelfth People's Hospital, Guangzhou, 510620, China. zwsgzcn@163.com.
Chao Qiang JiangGuangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
Ya Li JinGuangzhou Twelfth People's Hospital, Guangzhou, 510620, China.
Shiu Lun Au YeungSchool of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Kar Keung ChengInstitute of Applied Health Research, University of Birmingham, Birmingham, B15 2TT, UK.
Tai Hing LamSchool of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Lin XuSchool of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. xulin27@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-0537-922X

Funding

Natural Science Foundation of Guangdong 2015A030313891the Guangzhou Public Health Bureau 201102A211004011the Guangzhou Science and Technology Bureau, Guangzhou, China 2002Z2-E2051; 2012J5100041; 2013J4100031; 201704030132the Health Medical Research Fund in Hong Kong HMRF/13143241the Natural Science Foundation of China 82373661the Natural Science Foundation of Guangdong 2018A030313140the University of Birmingham, UK N/AThe University of Hong Kong Foundation for Educational Development and Research SN/1f/HKUF-DC; C20400.28505200
6 · The paper itself

Abstract

purposeWe examined the associations of soy product intake with all-cause, cardiovascular disease (CVD), and cancer mortality and mediations through CVD risk factors based on the Guangzhou Biobank Cohort Study (GBCS), and conducted updated meta-analyses.

methodsA total of 29,825 participants aged 50 + years were included. Causes of death were identified through record linkage. Soy product intake was assessed by food frequency questionnaire. Cox proportional hazards regression was used to analyze the associations between soy product intake and mortality, yielding hazard ratios (HRs) and 95% confidence intervals (CIs). Mediation analyses with CVD risk factors as mediators, and updated meta-analyses were conducted.

resultsDuring 454,689 person-years of follow-up, 6899 deaths occurred, including 2694 CVD and 2236 cancer. Participants who consumed soy product of 1-6 portions/week, versus no consumption, had significantly lower risks of all-cause and CVD mortality (adjusted HR (95% CI) 0.91 (0.86, 0.97) and 0.87 (0.79, 0.96), respectively). In participants who consumed soy product of ≥ 7 portions/week, the association of higher intake with lower CVD mortality was modestly mediated by total cholesterol (4.2%, 95% CI 1.0-16.6%). Updated meta-analyses showed that the highest level of soy product intake, versus the lowest, was associated with lower risks of all-cause and CVD mortality (pooled HR (95% CI) 0.92 (0.88, 0.96) and 0.92 (0.87, 0.98), respectively).

conclusionModerate and high soy product intake were associated with lower risks of all-cause and CVD mortality. Our findings provide support for current dietary guidelines recommending moderate soy product intake, and contribute additional evidence regarding the potential protective effects of high soy product intake.

Indexed as

Cardiovascular DiseasesNeoplasmsSoy FoodsBiological Specimen BanksCause of DeathChinaCohort StudiesDietFemaleHumansMaleMiddle AgedRisk FactorsCancerCardiovascular diseaseMediation analysisMortalitySoy product intake

Identifiers

PMID38520523

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.