ArticleWorld journal of clinical cases2024
Causal role of immune cells in obstructive sleep apnea hypopnea syndrome: Mendelian randomization study.
Article in World journal of clinical cases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Association Between the Nutritional Inflammatory Index and Obstructive Sleep Apnea Risk: Insights from the NHANES 2015-2020 and Mendelian Randomization Analyses.Healthcare (Basel, Switzerland) · 2025Article
- Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis.Frontiers in genetics · 2025Article
- Update on the aetiopathogenesis of obstructive sleep apnea: Role of inflammatory and immune mediated mechanisms.World journal of clinical cases · 2024Article
- Obstructive sleep apnea-hypopnea syndrome immunological relationship.World journal of clinical cases · 2024Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite being one of the most prevalent sleep disorders, obstructive sleep apnea hypoventilation syndrome (OSAHS) has limited information on its immunologic foundation. The immunological underpinnings of certain major psychiatric diseases have been uncovered in recent years thanks to the extensive use of genome-wide association studies (GWAS) and genotyping techniques using high-density genetic markers (
aimTo investigate the immune cells' association with OSAHS
methodsA comprehensive two-sample mendelian randomization study was conducted to investigate the causal relationship between immune cell characteristics and OSAHS. Summary statistics for each immune cell feature were obtained from the GWAS catalog. Information on 731 immune cell properties, such as morphologic parameters, median fluorescence intensity, absolute cellular, and relative cellular, was compiled using publicly available genetic databases. The results' robustness, heterogeneity, and horizontal pleiotropy were confirmed using extensive sensitivity examination.
resultsFollowing false discovery rate (FDR) correction, no statistically significant effect of OSAHS on immunophenotypes was observed. However, two lymphocyte subsets were found to have a significant association with the risk of OSAHS: Basophil %CD33dim HLA DR- CD66b- (OR = 1.03, 95%CI = 1.01-1.03,
conclusionThis study shows a strong link between immune cells and OSAHS through a gene approach, thus offering direction for potential future medical research.
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