Evidence map›Paper›PMID 38526046›Full record

Trial reportAntimicrobial agents and chemotherapy2024

Outcomes by

Jeffrey B Locke, Chris M Pillar, Mariana Castanheira, Cecilia G Carvalhaes, David Andes, Jalal A Aram, Christina Andrzejewski, Ken Bartizal, Anita F Das, Taylor Sandison and 2 more

Open access · hybridAbstract readClinical Trial, Phase III
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Fungal biofilms in human health and disease.Nature reviews. Microbiology · 2025
    Review
  8. Activity of Rezafungin Against Echinocandin Non-wild typeOpen forum infectious diseases · 2025
    Article
  9. New Perspectives on Antimicrobial Agents: Rezafungin.Antimicrobial agents and chemotherapy · 2025
    Review
  10. Review
  11. Recent increase inAntimicrobial agents and chemotherapy · 2024
    Article
  12. Article
  13. Article
  14. A Mini-Review of In Vitro Data forJournal of fungi (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Jeffrey B LockeCidara Therapeutics, Inc., San Diego, California, USA.ORCID 0000-0001-8145-0828
Chris M PillarScience and Operations, Microbiologics, Kalamazoo, Michigan, USA.
Mariana CastanheiraJMI Laboratories, North Liberty, Iowa, USA.ORCID 0000-0003-0126-1782
Cecilia G CarvalhaesJMI Laboratories, North Liberty, Iowa, USA.
David AndesDepartment of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7927-9950
Jalal A AramMedical Affairs, Melinta Therapeutics, LLC, Parsippany, New Jersey, USA.ORCID 0000-0001-5184-1182
Christina AndrzejewskiMedical Affairs, Melinta Therapeutics, LLC, Parsippany, New Jersey, USA.
Ken BartizalCidara Therapeutics, Inc., San Diego, California, USA.
Anita F DasCidara Therapeutics, Inc., San Diego, California, USA.
Taylor SandisonCidara Therapeutics, Inc., San Diego, California, USA.
George R ThompsonDivision of Infectious Diseases, Department of Internal Medicine and Department of Medical Microbiology and Immunology, University of California Davis Medical Center, Sacramento, California, USA.
Peter G PappasDivision of Infectious Diseases, Department of Internal Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Cidara Therapeutics (United States) · USJMI Laboratories · USMelinta Therapeutics (United States) · USMBio Diagnostics (United States) · USUniversity of Alabama at Birmingham · USUniversity of California Davis Medical Center · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rezafungin is a long-acting, intravenously administered echinocandin for the treatment of candidemia and invasive candidiasis (IC). Non-inferiority of rezafungin vs caspofungin for the treatment of adults with candidemia and/or IC was demonstrated in the Phase 3 ReSTORE study based on the primary endpoints of day 14 global cure and 30-day all-cause mortality. Here, an analysis of ReSTORE data evaluating efficacy outcomes by baseline

Indexed as

Antifungal AgentsCandidemiaCandidiasis, InvasiveCaspofunginEchinocandinsMicrobial Sensitivity TestsAdultAgedCandidaCandida albicansCandida glabrataCandida tropicalisFemaleHumansLipopeptidesMaleAntifungal AgentsCaspofunginEchinocandinsLipopeptidesRezafunginantifungal therapyCandida speciescandidemiaechinocandininvasive candidiasis

Identifiers

PMID38526046
PMCPMC11064504
OpenAlexW4393161252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.