Evidence map›Paper›PMID 38526652›Full record

ArticleVirchows Archiv : an international journal of pathology2024

COVID-19-associated secondary sclerosing cholangitis with liver transplantation.

Anne Kristin Fischer, Dirk Stippel, Ali Canbay, Dirk Nierhoff, Michael Thomas, Jan Best, Reinhard Büttner, Uta Drebber

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Anne Kristin FischerInstitute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. Anne.Kristin.Fischer@uk-koeln.de.ORCID http://orcid.org/0000-0003-0665-9693
Dirk StippelDepartment of Surgery, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.ORCID http://orcid.org/0000-0002-1107-0907
Ali CanbayDepartment of Internal Medicine, Transplant Medicine, Gastroenterology and Hepatology, University of Bochum, In Der Schornau 23-25 44892, Bochum, Germany.ORCID http://orcid.org/0000-0001-6069-7899
Dirk NierhoffDepartment of Internal Medicine, Gastroenterology and Hepatology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.ORCID http://orcid.org/0000-0001-7297-2675
Michael ThomasDepartment of Surgery, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.ORCID http://orcid.org/0000-0002-2875-9356
Jan BestDepartment of Internal Medicine, Transplant Medicine, Gastroenterology and Hepatology, University of Bochum, In Der Schornau 23-25 44892, Bochum, Germany.ORCID http://orcid.org/0000-0003-2074-0930
Reinhard BüttnerInstitute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.ORCID http://orcid.org/0000-0001-8806-4786
Uta DrebberInstitute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.ORCID http://orcid.org/0000-0002-2697-4685
University of Cologne · DEBochum University of Applied Sciences · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report on two cases of orthotopic liver transplantation (OLTX) due to SARS-Cov2-associated secondary sclerosing cholangitis (SSC) following long-term artificial respiration and extra-corporal membrane oxygenation in intensive care. Under these conditions, SSC is a rapidly progredient biliary disease featuring degenerative cholangiopathy, loss of bile ducts, ductular and parenchymal cholestasis, biliary fibrosis, and finally cirrhosis. Reduced perfusion and oxygenation of the peribiliary plexus, severe concurrent infections, and secondary medico-toxic effects appear to play a crucial role in the pathogenesis of the disease. A direct cytopathic effect of SARS-Cov2 on endothelial cells followed by thrombosis and fibrosing obliteration in all parts of the vascular bed of the liver may enhance the virus-associated liver disease and particularly SSC.

Indexed as

Cholangitis, SclerosingCOVID-19Liver TransplantationSARS-CoV-2HumansMaleMiddle AgedCOVID-19 infectionLiver pathologyLiver transplantationSecondary sclerosing cholangitisVasculopathy

Identifiers

PMID38526652
PMCPMC11329547
OpenAlexW4393147857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.