Evidence map›Paper›PMID 38527291›Full record

ArticleBlood advances2024

Impact of arginine therapy on kyotorphin in children with sickle cell disease and vaso-occlusive pain.

Rawan Korman, Dunia Hatabah, Lou Ann Brown, Frank Harris, Hagar Wilkinson, Chris A Rees, Nitya Bakshi, David R Archer, Carlton Dampier, Claudia R Morris

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02447874 phase1 / phase2recruitingnot on this map

Arginine Therapy for the Treatment of Vaso-Occlusive Events in Children With Severe Sickle Cell Disease

TypeinterventionalSponsorEmory UniversityRan2015 to 2028Enrolled21ConditionsSickle Cell DiseaseArmsArginine, Arginine (Loading), Arginine (Continuous)
NCT04839354 phase3completednot on this map

Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial

TypeinterventionalSponsorClaudia R. MorrisRan2021 to 2024Enrolled271ConditionsSickle Cell DiseaseArmsL-Arginine Hydrochloride, Normal saline
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rawan KormanDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0009-0009-9780-9589
Dunia HatabahDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0009-0006-6685-2902
Lou Ann BrownDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-9745-0619
Frank HarrisDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-8697-7186
Hagar WilkinsonChildren's Healthcare of Atlanta, Atlanta, GA.
Chris A ReesDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6449-0377
Nitya BakshiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-0876-9506
David R ArcherDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-9185-0865
Carlton DampierDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-7738-2620
Claudia R MorrisDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6019-2858
Emory University · USChildren's Healthcare of Atlanta · US

Funding

Georgia Clinical & Translational Science Alliance (Georgia CTSA)UL1TR002378 · EMORY UNIVERSITY · 2025 to 2025
$9.3M
Patient-Oriented Research in Arginine Deficiency SyndromesK24AT009893 · EMORY UNIVERSITY · 2025 to 2025
$142k
NCATS NIH HHS UL1 TR002378NCCIH NIH HHS K24 AT009893NHLBI NIH HHS K23 HL140142NHLBI NIH HHS R34 HL122557
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellArgininePainAdolescentChildEndorphinsFemaleHumansMaleArginineEndorphins

Identifiers

PMID38527291
PMCPMC11226964
OpenAlexW4393164678

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.