Evidence map›Paper›PMID 38528148›Full record

ArticleNature microbiology2024

TOLLIP inhibits lipid accumulation and the integrated stress response in alveolar macrophages to control Mycobacterium tuberculosis infection.

Sambasivan Venkatasubramanian, Courtney R Plumlee, Kimberly A Dill-McFarland, Sara B Cohen, Benjamin H Gern, Divya A Rane, Mackenzie K Meyer, Aparajita Saha, Sarah A Hinderstein, Gemma L Pearson and 8 more

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Infection and immunity · 2026
    Article
  6. Article
  7. [Active Oxygen Influences Foam Macrophage Formation by Regulating Peroxisome Proliferator-Activated Receptor-γ Expression].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  8. bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Sambasivan VenkatasubramanianDepartment of Medicine, University of Washington, Seattle, WA, USA.
Courtney R PlumleeSeattle Children's Research Institute, Seattle, WA, USA.
Kimberly A Dill-McFarlandDepartment of Medicine, University of Washington, Seattle, WA, USA.
Sara B CohenSeattle Children's Research Institute, Seattle, WA, USA.
Benjamin H GernSeattle Children's Research Institute, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0142-5970
Divya A RaneDepartment of Medicine, University of Washington, Seattle, WA, USA.
Mackenzie K MeyerDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0009-0003-1951-8088
Aparajita SahaDepartment of Medicine, University of Washington, Seattle, WA, USA.
Sarah A HindersteinDepartment of Medicine, University of Washington, Seattle, WA, USA.
Gemma L PearsonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Anne C LietzkeDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Amanda PachecoDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Yu-Hua ChowDepartment of Medicine, University of Washington, Seattle, WA, USA.
Chi F HungDepartment of Medicine, University of Washington, Seattle, WA, USA.
Scott A SoleimanpourDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6777-4498
Matthew AltmanDepartment of Medicine, University of Washington, Seattle, WA, USA.
Kevin B UrdahlSeattle Children's Research Institute, Seattle, WA, USA.
Javeed A ShahDepartment of Medicine, University of Washington, Seattle, WA, USA. jashah@uw.edu.ORCID http://orcid.org/0000-0002-2997-7988
University of Washington · USUniversity of Michigan · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Martin G Myers · 2013 to 2026
$24.3M
Systems Biology, Bioinformatics, & Data IntegrationU19AI162583 · NIAID · UNIVERSITY OF WASHINGTON · PI COX, JEFFERY S, HAWN, THOMAS R · 2021 to 2025
$13.0M
Type 2 diabetes risk variant effects on mitochondrial (patho)physiologyR01DK136671 · NIDDK · JACKSON LABORATORY · PI Scott Soleimanpour, Michael Lee Stitzel · 2023 to 2026
$3.0M
A Stress-Induced Vicious Cycle In The Development of T1DU01DK127747 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ARVAN, PETER, SATIN, LESLIE S. · 2020 to 2023
$2.8M
Functional diversity of lung pericytes in lung injuryR01HL166273 · NHLBI · UNIVERSITY OF WASHINGTON · PI Chi F Hung · 2023 to 2026
$2.5M
TOLLIP Deficiency, Immune Dysregulation, and Tuberculosis SusceptibilityR01AI136921 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2018 to 2022
$2.5M
Control of insulin secretion by mitochondrial fusionR01DK135268 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Brett A Kaufman, Scott Soleimanpour · 2023 to 2026
$2.4M
Mediators of mitophagy in the regulation of beta cell functionR01DK108921 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SOLEIMANPOUR, SCOTT · 2016 to 2020
$1.9M
Dissecting the molecular regulation of T cell localization and function within the Mycobacterium tuberculosis granulomaK08AI166072 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Benjamin Henry Gern · 2022 to 2026
$929k
TOLLIP and Tuberculosis ImmunopathogenesisK08AI102971 · NIAID · UNIVERSITY OF WASHINGTON · PI SHAH, JAVEED ALI · 2013 to 2016
$708k
Symptom Cluster Subgroups in Adult Survivors of Childhood CancersR01CA136912 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FINNEGAN, LORNA · 2009 to 2010
$478k
Acquisition of BD FACSymphony A3 Lite Flow CytometerS10OD024979 · OD · UNIVERSITY OF WASHINGTON · PI BLACK, MICHELE C · 2020 to 2020
$344k
BLRD VA I01 BX004444NCI NIH HHS R01 CA136912NHLBI NIH HHS R01 HL166273NHLBI NIH HHS R03 HL155075NIAID NIH HHS K08 AI102971NIAID NIH HHS K08 AI166072NIAID NIH HHS L30 AI091018NIAID NIH HHS R01 AI136921NIAID NIH HHS U19 AI162583NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK108921NIDDK NIH HHS R01 DK135268NIDDK NIH HHS R01 DK136671NIDDK NIH HHS U01 DK127747NIH HHS S10 OD024979
6 · The paper itself

Abstract

A polymorphism causing deficiencies in Toll-interacting protein (TOLLIP), an inhibitory adaptor protein affecting endosomal trafficking, is associated with increased tuberculosis (TB) risk. It is, however, unclear how TOLLIP affects TB pathogenesis. Here we show that TB severity is increased in Tollip

Indexed as

Mycobacterium tuberculosisTuberculosisAnimalsIntracellular Signaling Peptides and ProteinsLipidsMacrophagesMacrophages, AlveolarMiceIntracellular Signaling Peptides and ProteinsLipidsTollip protein, mouse

Identifiers

PMID38528148
PMCPMC11034867
OpenAlexW4393159667

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.