Evidence map›Paper›PMID 38528305›Full record

ArticleMolecular neurobiology2024

Circ-Bptf Ameliorates Learning and Memory Impairments via the miR-138-5p/p62 Axis in APP/PS1 Mice.

Hong-Fang Wang, Yi-Bo Li, Zi-Yu Liu, Wen-Meng Xie, Qing Liu, Run-Jiao Zhang, Wen-Yu Wang, Jia-Xin Hao, Lei Wang, Dan-Dan Geng

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In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hong-Fang WangDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Yi-Bo LiDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Zi-Yu LiuDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Wen-Meng XieDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Qing LiuDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Run-Jiao ZhangDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Wen-Yu WangDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Jia-Xin HaoDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Lei WangDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. wanglei@hebmu.edu.cn.
Dan-Dan GengDepartment of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. gengdandan@hebmu.edu.cn.ORCID http://orcid.org/0000-0002-0511-1653
Hebei Medical University · CN

Funding

National Natural Science Foundation of China 82071594Natural Science Foundation of Hebei Province C2020206037Natural Science Foundation of Hebei Province H2020206299Natural Science Foundation of Hebei Province H2023206164Natural Science Foundation of Hebei Province H2023206258
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common age-associated progressive neurodegenerative disorder that is implicated in the aberrant regulation of numerous circular RNAs (circRNAs). Here, we reported that circ-Bptf, a conserved circRNA derived from the Bptf gene, showed an age-dependent decrease in the hippocampus of APP/PS1 mice. Overexpression of circ-Bptf significantly reversed dendritic spine loss and learning and memory impairment in APP/PS1 mice. Moreover, we found that circ-Bptf was predominantly localized to the cytoplasm and upregulated p62 expression by binding to miR-138-5p. Furthermore, the miR-138-5p mimics reversed the decreased expression of p62 induced by the silencing of circ-Bptf. Together, our findings suggested that circ-Bptf ameliorated learning and memory impairments via the miR-138-5p/p62 axis in APP/PS1 mice. It may act as a potential player in AD pathogenesis and therapy.

Indexed as

Memory DisordersMicroRNAsRNA, CircularAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsDendritic SpinesHippocampusLearningMaleMiceMice, Inbred C57BLMice, TransgenicPresenilin-1Transcription FactorsAmyloid beta-Protein PrecursorMicroRNAsMIRN138 microRNA, mousePresenilin-1RNA, CircularTranscription FactorsAlzheimer's diseaseCirc-BptfLearning and memorymiR-138-5pp62

Identifiers

PMID38528305
OpenAlexW4393164649

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.