Evidence map›Paper›PMID 38528596›Full record

ArticleClinical epigenetics2024

A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure.

Sandra Fitzgerald, Basharat Bhat, Cristin Print, Gregory T Jones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sandra FitzgeraldDepartment of Molecular Medicine & Pathology, The University of Auckland, Auckland, New Zealand.
Basharat BhatVascular Research Group, Department of Surgical Sciences, Dunedin Medical School, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
Cristin PrintDepartment of Molecular Medicine & Pathology, The University of Auckland, Auckland, New Zealand.
Gregory T JonesVascular Research Group, Department of Surgical Sciences, Dunedin Medical School, University of Otago, PO Box 56, Dunedin, 9054, New Zealand. greg.jones@otago.ac.nz.
University of Otago · NZMaurice Wilkins Centre · NZUniversity of Auckland · NZ

Funding

Health Research Council of New Zealand 14/155Health Research Council of New Zealand 17/402Health Research Council of New Zealand 20/144
6 · The paper itself

Abstract

BACKGROUND &

methodsIn this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obtained by bisulfite conversion (BIS) ddPCR and Illumina DNA methylation array.

resultsThe RE ddPCR cg05575921 assay appeared concordant with BIS ddPCR (r

conclusionsThe RE ddPCR cg05575921 assay accurately predicts smoking status and could be a useful component of 'precision-medicine' chronic disease risk screening tools.

Indexed as

DNA MethylationSmokingBasic Helix-Loop-Helix ProteinsHumansPolymerase Chain ReactionRepressor ProteinsAHRR protein, humanBasic Helix-Loop-Helix ProteinsRepressor ProteinsAryl hydrocarbon receptor repressor (AHRR)Bisulfite conversionDNA methylationDroplet digital PCREpigeneticsRestriction enzymeSmoking exposure

Identifiers

PMID38528596
PMCPMC10962207
OpenAlexW4393155743

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.