SynthesisFrontiers in endocrinology2024
Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses.
Synthesis in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Association between relative fat mass and increased prevalence of gallstone disease in American adults: A cross-sectional study.Medicine · 2026Article
- Enhanced prediction of cholecystectomy using obesity-modified TyG indices: a machine learning and SHAP-based study.European journal of medical research · 2025Article
- Unpacking the association between chewing capacity and gallstone prevalence: a cross-sectional analysis of NHANES data.International journal of surgery (London, England) · 2025Article
- Association between dietary fiber intake and gallstones among American adults: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Cholecystectomy in Children: Indications and Timing.Children (Basel, Switzerland) · 2025Article
- Explainable machine learning-driven models for predicting Parkinson's disease and its prognosis: obesity patterns associations and models development using NHANES 1999-2018 data.Lipids in health and disease · 2025Article
- Obesity and Pancreatic Diseases: From Inflammation to Oncogenesis and the Impact of Weight Loss Interventions.Nutrients · 2025Review
- Long-term weight change patterns in American adulthood in relation to gallstones: evidence from NHANES.BMC gastroenterology · 2025Article
- Association between relative fat mass and risk of gallstones in adults.Scientific reports · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Gallstones after bariatric surgery: mechanisms and prophylaxis.Frontiers in surgery · 2025Review
- Differences in Weight Loss Postsleeve Gastrectomy Among Patients With Various Types of Obesity Based on Waist-To-Hip Ratio Classification.Journal of obesity · 2025Article
- Association between ZJU index and gallstones in US adult: a cross-sectional study of NHANES 2017-2020.BMC gastroenterology · 2024Article
- Association between triglyceride glucose index-related indices with gallstone disease among US adults.Lipids in health and disease · 2024Article
- Follow-up study of gallbladder stones in 44 children.World journal of clinical cases · 2024Article
- Physical activity and risk of cholelithiasis: a narrative review.Frontiers in medicine · 2024Review
- Elevated metabolic score for visceral fat was associated with increased prevalence of gallstones in American adults: a cross-sectional study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD. Methods: We first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using data from UK Biobank (N=472,050). We then explored the genetic relationship using summary statistics from the largest genome-wide association study of GSD ( Results: Observational analysis demonstrated an increased risk of GSD with one unit increase in WHR (HR=1.18, 95%CI=1.14-1.21). A positive WHR-GSD genetic correlation ( Conclusion: Both observational and genetic analyses consistently provide evidence on an association of central obesity with an increased risk of GSD, independent of general obesity. Our work highlights the need of considering both general and central obesity in the clinical management of GSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.