Evidence map›Paper›PMID 38529622›Full record

ArticleMolecular pharmaceutics2024

Rifampin- and Silymarin-Mediated Pharmacokinetic Interactions of Exogenous and Endogenous Substrates in a Transgenic OATP1B Mouse Model.

Baron J Bechtold, Katherine D Lynch, Victoria O Oyanna, M Ridge Call, Tyler N Graf, Nicholas H Oberlies, John D Clarke

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Development and hepatotoxicity of rifamycin derivatives.Expert opinion on drug metabolism & toxicology · 2025
    Review
  3. OATP1B1/1B3 deficiency exacerbates hyperbilirubinemia in erythropoietic protoporphyria.Drug metabolism and disposition: the biological fate of chemicals · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Baron J BechtoldDepartment of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.ORCID 0009-0006-4287-1877
Katherine D LynchDepartment of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.
Victoria O OyannaDepartment of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.
M Ridge CallDepartment of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.
Tyler N GrafDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.ORCID 0000-0003-4145-2815
Nicholas H OberliesDepartment of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.ORCID 0000-0002-0354-8464
John D ClarkeDepartment of Pharmaceutical Sciences, Washington State University, 412 E. Spokane Falls Blvd., Spokane, Washington 99202, United States.ORCID 0000-0003-3835-7761
Washington State University Spokane · USUniversity of North Carolina at Greensboro · US

Funding

Risk of xenobiotic-drug interactions in chronic diseaseR56AT010650 · NCCIH · WASHINGTON STATE UNIVERSITY · PI CLARKE, JOHN DANIEL · 2020 to 2020
$223k
NCCIH NIH HHS R56 AT010650
6 · The paper itself

Abstract

Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3, encoded by the

Indexed as

Drug InteractionsLiver-Specific Organic Anion Transporter 1Mice, TransgenicPravastatinRifampinSilymarinSolute Carrier Organic Anion Transporter Family Member 1B3AnimalsCoproporphyrinsHumansMaleMiceOrganic Anion TransportersQuinolinescoproporphyrin Icoproporphyrin IIICoproporphyrinsLiver-Specific Organic Anion Transporter 1Organic Anion TransporterspitavastatinPravastatinQuinolinesRifampinSilymarinSLCO1B1 protein, humanSLCO1B3 protein, humanSolute Carrier Organic Anion Transporter Family Member 1B3drug−drug interactionhumanized OATP1B micenatural product−drug interactionOATPpharmacokineticstransporters

Identifiers

PMID38529622
PMCPMC11073900
OpenAlexW4393193620

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.