Evidence map›Paper›PMID 38529835›Full record

ReviewAdvanced healthcare materials2024

Biofabrication Strategies for Oral Soft Tissue Regeneration.

Maedeh Rahimnejad, Hardik Makkar, Renan Dal-Fabbro, Jos Malda, Gopu Sriram, Marco C Bottino

Open access · hybridAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026
    Review
  3. Article
  4. Article
  5. The Effect of the ErMaterials (Basel, Switzerland) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Biofabrication - Revolutionizing the future of regenerative periodontics.Dental materials : official publication of the Academy of Dental Materials · 2025
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Maedeh RahimnejadDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2958-1115
Hardik MakkarFaculty of Dentistry, National University of Singapore, Singapore, 119085, Singapore.ORCID 0000-0002-8416-4138
Renan Dal-FabbroDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-4125-8441
Jos MaldaRegenerative Medicine Center Utrecht, Utrecht, 3584, The Netherlands.ORCID 0000-0002-9241-7676
Gopu SriramFaculty of Dentistry, National University of Singapore, Singapore, 119085, Singapore.ORCID 0000-0001-8423-5197
Marco C BottinoDepartment of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-8740-2464
University of Michigan · USNational University of Singapore · SGUniversity of Applied Sciences Utrecht · NL

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
Combined bioprinting with stem cell technology to regenerate skin burn woundsR01GM143938 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C, CASTILHO, ROGERIO MORAES · 2021 to 2024
$2.0M
National University Healthcare System and Singapore Ministry of Education A-8000164-00-00National University Healthcare System and Singapore Ministry of Education NUHSRO/2021/107/RO5+6/Seed-Sep/10NIDCR NIH HHS R01 DE031476NIDCR NIH HHS R01DE031476NIGMS NIH HHS R01 GM143938NIGMS NIH HHS R01GM143938
6 · The paper itself

Abstract

Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the exposure of tooth root surfaces due to the displacement of the gingival margin. This review explores conventional treatments, highlighting their limitations and the quest for innovative alternatives. Importantly, it emphasizes the critical considerations in gingival tissue engineering leveraging on cells, biomaterials, and signaling factors. Successful tissue-engineered gingival constructs hinge on strategic choices such as cell sources, scaffold design, mechanical properties, and growth factor delivery. Unveiling advancements in recent biofabrication technologies like 3D bioprinting, electrospinning, and microfluidic organ-on-chip systems, this review elucidates their precise control over cell arrangement, biomaterials, and signaling cues. These technologies empower the recapitulation of microphysiological features, enabling the development of gingival constructs that closely emulate the anatomical, physiological, and functional characteristics of native gingival tissues. The review explores diverse engineering strategies aiming at the biofabrication of realistic tissue-engineered gingival grafts. Further, the parallels between the skin and gingival tissues are highlighted, exploring the potential transfer of biofabrication approaches from skin tissue regeneration to gingival tissue engineering. To conclude, the exploration of innovative biofabrication technologies for gingival tissues and inspiration drawn from skin tissue engineering look forward to a transformative era in regenerative dentistry with improved clinical outcomes.

Indexed as

RegenerationTissue EngineeringTissue ScaffoldsAnimalsBiocompatible MaterialsBioprintingGingivaGingival RecessionHumansPrinting, Three-DimensionalBiocompatible Materialsbiofabricationbioprintinggingival recessionregenerationskintissue engineering

Identifiers

PMID38529835
PMCPMC11254569
OpenAlexW4393199983

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.