Evidence map›Paper›PMID 38532173›Full record

ArticleAnnals of biomedical engineering2024

The 'bIUreactor': An Open-Source 3D Tissue Research Platform.

Elizabeth Butch, Matthew Prideaux, Mark Holland, Justin-Thuy Phan, Cole Trent, Victor Soon, Gary Hutchins, Lester Smith

Abstract read
In one paragraph

Article in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elizabeth ButchDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Matthew PrideauxIndiana Center for Musculoskeletal Health, Indiana University School of Medicine, Indianapolis, IN, USA.
Mark HollandDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Justin-Thuy PhanSmith BioFab Lab, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Cole TrentSmith BioFab Lab, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Victor SoonDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Gary HutchinsDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Lester SmithSmith BioFab Lab, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. smitlej@iu.edu.ORCID http://orcid.org/0000-0003-4950-7569

Funding

Interdisciplinary Training in Auditory NeuroscienceT32DC016853 · NIDCD · PURDUE UNIVERSITY · PI Edward Bartlett, Michael G Heinz · 2018 to 2026
$1.5M
NIDCD NIH HHS T32 DC016853
6 · The paper itself

Abstract

We developed the open-source bIUreactor research platform for studying 3D structured tissues. The versatile and modular platform allows a researcher to generate 3D tissues, culture them with oxygenated perfusion, and provide cyclic loading, all in their own lab (in laboratorium) for an all in cost of $8,000 including 3D printer, printing resin, and electronics. We achieved this by applying a design philosophy that leverages 3D printing, open-source software and hardware, and practical techniques to produce the following: 1. perfusible 3D tissues, 2. a bioreactor chamber for tissue culture, 3. a module for applying cyclic compression, 4. a peristaltic pump for providing oxygenated perfusion to 3D tissues, 5. motor control units, and 6. open-source code for running the control units. By making it widely available for researchers to investigate 3D tissue models and easy for them to use, we intend for the bIUreactor to democratize 3D tissue research, therefore increasing the pace and scale of biomedical research discoveries using 3D tissue models.

Indexed as

BioreactorsPrinting, Three-DimensionalAnimalsHumansSoftwareTissue Engineering3D printing3D tissueBiofabricationBioprintingBioreactorHardwareOpen-sourceTissue cultureTissue engineering

Identifiers

PMID38532173
PMCPMC11082015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.