Evidence map›Paper›PMID 38532299›Full record

ArticleEuropean journal of neurology2024

Pre-morbid sleep disturbance and its association with stroke severity: results from the international INTERSTROKE study.

Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Shahram Oveis Gharan, Albertino Damasceno, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah and 6 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 11 countries.

Christine E Mc CarthyHRB Clinical Research Facility, University of Galway, Galway, Ireland.ORCID 0000-0002-8703-0661
Salim YusufPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Conor JudgeHRB Clinical Research Facility, University of Galway, Galway, Ireland.
John FergusonHRB Clinical Research Facility, University of Galway, Galway, Ireland.
Graeme J HankeyMedical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Shahram Oveis GharanRush Alzheimer Disease Centre, Rush University Medical Centre, Chicago, Illinois, USA.
Albertino DamascenoFaculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Helle Klingenberg IversenDepartment of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Annika RosengrenMolecular and Clinical Medicine, Gothenburg University, Gothenburg, Sweden.
Okechukwu OgahCardiology Unit, Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Luísa AvezumNeurology Department, Hospital Santa Marcelina, Sao Paulo, Brazil.
Patricio Lopez-JaramilloDirector de Investigaciones Facultad de Medicina, Universidad de Santander, Bucaramanga-Santander, Colombia.
Denis XavierPharmacology and Clinical Research and Training, St John's Medical College and Research Institute, Bangalore, India.
Xingyu WangBeijing Hypertension League Institute, Beijing, China.
Sumathy RangarajanPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Martin J O'DonnellHRB Clinical Research Facility, University of Galway, Galway, Ireland.
Population Health Research Institute · CAEduardo Mondlane University · MZHospital Santa Marcelina · BRRush University Medical Center · USShanghai Institute of Hypertension · CNSt.John's Medical College Hospital · INThe University of Western Australia · AUUniversidad De Santander · COUniversity of Copenhagen · DKUniversity of Gothenburg · SEUniversity of Ibadan · NG

Funding

CIHRNIH HHS
6 · The paper itself

Abstract

background and purposeWhilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated.

methodsINTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361). Two indices were derived representing sleep disturbance (range 0-9) and obstructive sleep apnoea (range 0-3) symptoms. Logistic regression was used to estimate the magnitude of association between symptoms and stroke severity defined by the modified Rankin Score.

resultsThe mean age of participants was 62.9 years, and 42% were female. On multivariable analysis, there was a graded association between increasing number of sleep disturbance symptoms and initially severe stroke (2-3, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.07-1.94; 4-5, OR 1.66, 95% CI 1.23-2.25; >5, OR 2.58, 95% CI 1.83-3.66). Having >5 sleep disturbance symptoms was associated with significantly increased odds of functional deterioration at 1 month (OR 1.54, 95% CI 1.01-2.34). A higher obstructive sleep apnoea score was also associated with significantly increased odds of initially severe stroke (2-3, OR 1.48; 95% CI 1.20-1.83) but not functional deterioration at 1 month (OR 1.19, 95% CI 0.93-1.52).

conclusionsSleep disturbance symptoms were common and associated with an increased odds of severe stroke and functional deterioration. Interventions to modify sleep disturbance may help prevent disabling stroke/improve functional outcomes and should be the subject of future research.

Indexed as

Severity of Illness IndexSleep Wake DisordersStrokeAgedCase-Control StudiesFemaleHumansMaleMiddle Ageddisability evaluationsleepsleep apnea, obstructivesleep initiation and maintenance disordersstroke

Identifiers

PMID38532299
PMCPMC11235977
OpenAlexW4393229624

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.