Evidence map›Paper›PMID 38533496›Full record

ReviewFrontiers in immunology2024

Role of differentiated embryo-chondrocyte expressed gene 2 in immunity.

Yujing Li, Yinan Ma, Yang Liu, Na Tang, Wenzhu Zhang, Jingru Huo, Di Zhang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yujing Li *Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Yinan Ma *Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Yang Liu *Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Na Tang *Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Wenzhu Zhang *Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Jingru Huo *Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Di ZhangDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
First Hospital of China Medical University · CNChina Medical University · CNSichuan Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Differentiated embryo-chondrocyte expressed gene 2 (DEC2) is a member of the basic helix-loop-helix (bHLH) subfamily of transcription factors. DEC2 is implicated in tumor immunotherapy, immune system function regulation, and autoimmune diseases. DEC2 enhances Th2 cell differentiation by regulating the IL-2 and IL-4 signaling pathways and mediates the growth of B-1a cells, thereby promoting the occurrence and development of inflammatory responses. In this study, we review the reported roles of DEC2, including the regulation of immune cell differentiation and cytokine production in various cells in humans, and discuss its potential in treating autoimmune diseases and tumors.

Indexed as

Autoimmune DiseasesBasic Helix-Loop-Helix ProteinsChondrocytesGene ExpressionHumansTranscription FactorsBasic Helix-Loop-Helix ProteinsTranscription FactorsBhlhe41DEC1DEC2immune cellsimmunity

Identifiers

PMID38533496
PMCPMC10963606
OpenAlexW4392712420

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.