Evidence map›Paper›PMID 38534100›Full record

ArticleInfection and immunity2024

Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenic

Adam J Lewis, Amanda C Richards, Alejandra A Mendez, Bijaya K Dhakal, Tiffani A Jones, Jamie L Sundsbak, Danelle S Eto, Alexis A Rousek, Matthew A Mulvey

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Current Insights into Antibiotic Resistance in UropathogenicAntibiotics (Basel, Switzerland) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Adam J Lewis *Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Amanda C Richards *Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Alejandra A MendezDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Bijaya K DhakalDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Tiffani A JonesDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Jamie L SundsbakDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Danelle S EtoDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.
Alexis A RousekSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.
Matthew A MulveyDivision of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-6016-7510
University of Utah · US

Funding

RESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4M
Training Program in Microbial PathogenesisT32AI055434 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A, PLANELLES, VICENTE · 2004 to 2025
$6.0M
Bacterial Invasion and Trafficking within the BladderR01AI095647 · NIAID · UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A · 2011 to 2015
$1.8M
Impact of Flagellin Variants and Receptors on the Progression and Outcome of SepsisR01GM134331 · NIGMS · UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A · 2019 to 2022
$1.6M
Control of bladder infections by NF-kappaBR21DK069526 · NIDDK · UNIVERSITY OF UTAH · PI MULVEY, MATTHEW A · 2004 to 2005
$336k
NIAID NIH HHS R01 AI095647NIAID NIH HHS T32 AI055434NIDDK NIH HHS R21 DK069526NIDDK NIH HHS T32 DK007115NIGMS NIH HHS R01 GM134331
6 · The paper itself

Abstract

Traditional folk treatments for the prevention and management of urinary tract infections (UTIs) and other infectious diseases often include plants and plant extracts that are rich in phenolic compounds. These have been ascribed a variety of activities, including inhibition of bacterial interactions with host cells. Here, we tested a panel of four well-studied phenolic compounds-caffeic acid phenethyl ester (CAPE), resveratrol, catechin, and epigallocatechin gallate-for the effects on host cell adherence and invasion by uropathogenic

Indexed as

Escherichia coli InfectionsFocal Adhesion Kinase 1PhenolsPlant ExtractsUrinary Tract InfectionsUropathogenic Escherichia coliAnimalsBacterial AdhesionCaffeic AcidsCatechinCell LineEpithelial CellsFemaleHumansMicePhenylethyl Alcoholcaffeic acid phenethyl esterCaffeic AcidsCatechinepigallocatechin gallateFocal Adhesion Kinase 1PhenolsPhenylethyl AlcoholPlant ExtractsResveratrolactinbladderFAKinvasionphenolicSalmonellaShigellaUPECurinary tract infectionUTI

Identifiers

PMID38534100
PMCPMC11075462
OpenAlexW4393223364

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.