Evidence map›Paper›PMID 38534538›Full record

ReviewBioengineering (Basel, Switzerland)2024

Applications of Intravital Imaging in Cancer Immunotherapy.

Deqiang Deng, Tianli Hao, Lisen Lu, Muyang Yang, Zhen Zeng, Jonathan F Lovell, Yushuai Liu, Honglin Jin

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Optical and Photoacoustic Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Deqiang DengCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Tianli HaoCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Lisen LuCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Muyang YangCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Zhen ZengCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.ORCID 0000-0002-9052-884X
Yushuai LiuDepartment of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Honglin JinCollege of Biomedicine and Health and College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Huazhong Agricultural University · CNUnion Hospital · CNUniversity at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, immunotherapy is one of the most effective treatment strategies for cancer. However, the efficacy of any specific anti-tumor immunotherapy can vary based on the dynamic characteristics of immune cells, such as their rate of migration and cell-to-cell interactions. Therefore, understanding the dynamics among cells involved in the immune response can inform the optimization and improvement of existing immunotherapy strategies. In vivo imaging technologies use optical microscopy techniques to visualize the movement and behavior of cells in vivo, including cells involved in the immune response, thereby showing great potential for application in the field of cancer immunotherapy. In this review, we briefly introduce the technical aspects required for in vivo imaging, such as fluorescent protein labeling, the construction of transgenic mice, and various window chamber models. Then, we discuss the elucidation of new phenomena and mechanisms relating to tumor immunotherapy that has been made possible by the application of in vivo imaging technology. Specifically, in vivo imaging has supported the characterization of the movement of T cells during immune checkpoint inhibitor therapy and the kinetic analysis of dendritic cell migration in tumor vaccine therapy. Finally, we provide a perspective on the challenges and future research directions for the use of in vivo imaging technology in cancer immunotherapy.

Indexed as

adoptive cell therapycancer immunotherapyimmune cell trackingimmune checkpoint inhibitorintravital imagingnanoparticle

Identifiers

PMID38534538
PMCPMC10968666
OpenAlexW4392616265

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.