Evidence map›Paper›PMID 38535817›Full record

ArticleToxins2024

Red Orange and Lemon Extract Ameliorates the Renal Oxidative Stress and Inflammation Induced by Ochratoxin A through the Modulation of Nrf2.

Consiglia Longobardi, Sara Damiano, Simona Fabroni, Serena Montagnaro, Valeria Russo, Emanuela Vaccaro, Antonio Giordano, Salvatore Florio, Roberto Ciarcia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Consiglia LongobardiDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.ORCID 0000-0002-0788-4107
Sara DamianoDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.ORCID 0000-0001-7798-7710
Simona FabroniCouncil for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, C.so Savoia n.190, 95024 Acireale, Italy.ORCID 0000-0002-2567-6838
Serena MontagnaroDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.ORCID 0000-0001-5569-8774
Valeria RussoDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.
Emanuela VaccaroDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-5959-016X
Salvatore FlorioDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.ORCID 0000-0001-6805-4775
Roberto CiarciaDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via F. Delpino n.1, 80137 Naples, Italy.ORCID 0000-0003-4121-4905
University of Naples Federico II · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS). In this context, the use of natural antioxidant substances could be a potential biological decontamination method of mitigating the negative outcomes induced by OTA.

methodswe aimed to investigate how a red orange and lemon extract (RLE), rich in anthocyanins, would affect OTA-treated rats. The current work sought to clarify the renal protective efficacy of RLE in an OTA-treated rat model (RLE (90 mg/kg b.w.); OTA (0.5 mg/kg b.w.)) by investigating, thorough Western blot analysis, the involvement of the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. The OS parameters and inflammatory status were evaluated by spectrophotometry. The inflammatory infiltrates in the kidney were evaluated by immunohistochemical assays. RESULTS AND

conclusionOur findings showed a significant increase in oxidative and inflammatory parameters after OTA exposure, while the OTA + RLE co-treatment counteracted both the inflammatory and OS damage through the modulation of the Nrf2 pathway.

Indexed as

AnthocyaninsNF-E2-Related Factor 2OchratoxinsAnimalsAntioxidantsInflammationKidneyOxidative StressRatsAnthocyaninsAntioxidantsNF-E2-Related Factor 2ochratoxin AOchratoxinskidneyNrf2OTA toxicityRLEROS

Identifiers

PMID38535817
PMCPMC10975592
OpenAlexW4392863969

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.