Evidence map›Paper›PMID 38535959›Full record

ReviewToxics2024

Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview.

Jamila Alessandra Perini, Jessica Vilarinho Cardoso, Alana de Oliveira Knesse, Felipe Oliveira Pessoa-Silva, Ana Claudia Santiago de Vasconcellos, Daniel Escorsim Machado, Paulo Cesar Basta

Open access · goldAbstract readReview
In one paragraph

Review in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Influence of theInternational journal of environmental research and public health · 2026
    Article
  3. Article
  4. Article
  5. TheToxics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jamila Alessandra PeriniResearch Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.ORCID 0000-0002-7683-0698
Jessica Vilarinho CardosoResearch Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.ORCID 0000-0002-6758-3664
Alana de Oliveira KnesseResearch Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.
Felipe Oliveira Pessoa-SilvaResearch Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.
Ana Claudia Santiago de VasconcellosLaboratório de Educação Profissional em Vigilância em Saúde, Escola Politécnica de Saúde Joaquim Venâncio, Fundação Oswaldo Cruz (EPSJV/Fiocruz), Av. Brasil, 4365-Manguinhos, Rio de Janeiro 21040-900, Brazil.
Daniel Escorsim MachadoResearch Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.
Paulo Cesar BastaProgram of Post-Graduation in Public Health and Environment, National School of Public Health (ENSP), Oswald Cruz Foundation (Fiocruz), Rio de Janeiro 21041-210, Brazil.ORCID 0000-0003-0804-0413
Universidade do Estado do Rio de Janeiro · BRFundação Oswaldo Cruz · BR

Funding

Brazilian agency Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/210.059/2023Conselho Nacional de Desenvolvimento Científico e Tecnológico 408181/2022-2
6 · The paper itself

Abstract

Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations. Observational and experimental studies were identified by screening three databases. Thirteen articles were included (quality score 82-100%) and 8124 individuals were evaluated. Hg exposure was mainly fish consumption (77%) and, in 31% of the studies, the Hg levels exceeded the reference limits. Genetic susceptibility to higher Hg levels and neurotoxicity risk in Hg poisoning were associated with eight (

Indexed as

environmental healthgenetic polymorphismmercury exposuremercury poisoningneurotoxicitytoxicokinetic

Identifiers

PMID38535959
PMCPMC10975854
OpenAlexW4393003107

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.