Evidence map›Paper›PMID 38536494›Full record

ReviewPflugers Archiv : European journal of physiology2024

The role of Na

Shannon R Holmberg, Yohei Sakamoto, Akira Kato, Michael F Romero

Open access · greenAbstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Inactivation mechanisms of NaCommunications biology · 2025
    Article
  5. Beyond SGLT2: proximal tubule transporters as potential drug targets for chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shannon R HolmbergPhysiology & Biomedical Engineering, Mayo Clinic College of Medicine & Science, 200 1st Street SW, Rochester, MN 55905, USA.ORCID 0000-0003-2442-0029
Yohei SakamotoSchool of Life Science and Technology, Tokyo Institute of Technology, Midori-Ku, Yokohama, 226-8501, Japan.ORCID 0009-0007-0192-0422
Akira KatoSchool of Life Science and Technology, Tokyo Institute of Technology, Midori-Ku, Yokohama, 226-8501, Japan.ORCID 0000-0002-9083-1443
Michael F RomeroPhysiology & Biomedical Engineering, Mayo Clinic College of Medicine & Science, 200 1st Street SW, Rochester, MN 55905, USA. romero.michael@mayo.edu.ORCID 0000-0002-1555-7835
Mayo Clinic · USTokyo Institute of Technology · JP

Funding

CALCIUM DYNAMICS IN INTERSTITIAL CELLS OF CAJALR01DK057061 · NIDDK · MAYO CLINIC ROCHESTER · PI GIANRICO FARRUGIA, Tamas Ordog · 2000 to 2026
$8.2M
Mayo Clinic Summer Undergraduate Research in Nephrology & UrologyR25DK101405 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL F. ROMERO · 2014 to 2026
$1.6M
CHARACTERIZATION OF THE NA+-DRIVEN ANION EXCHANGER,NDAE1R01DK056218 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI ROMERO, MICHAEL F · 2000 to 2004
$1.4M
Role of pH-mediated metabolic reprogramming in β cell failure in Type 2 Diabetes MellitusR01DK128844 · NIDDK · MAYO CLINIC ROCHESTER · PI MATVEYENKO, ALEKSEY V, ROMERO, MICHAEL F. · 2021 to 2023
$1.3M
Assaying and controlling the kidney cell function using a genetically encoded pH-sensorR21DK129897 · NIDDK · MAYO CLINIC ROCHESTER · PI ROMERO, MICHAEL F. · 2022 to 2023
$437k
NIDDK NIH HHS R01 DK056218NIDDK NIH HHS R01 DK057061NIDDK NIH HHS R01 DK128844NIDDK NIH HHS R21 DK129897NIDDK NIH HHS R25 DK101405NIH HHS DK057061, DK101405, DK128844, DK129897
6 · The paper itself

Abstract

Cellular and organism survival depends upon the regulation of pH, which is regulated by highly specialized cell membrane transporters, the solute carriers (SLC) (For a comprehensive list of the solute carrier family members, see: https://www.bioparadigms.org/slc/ ). The SLC4 family of bicarbonate (HCO

Indexed as

BicarbonatesSodium-Bicarbonate SymportersHydrogen-Ion ConcentrationMembrane Transport ProteinsSodiumSodium BicarbonateBicarbonatesMembrane Transport ProteinsSodiumSodium BicarbonateSodium-Bicarbonate SymportersAnimal SLC4 gene evolutionAnion exchangeBicarbonateChlorideMonogenic diseaseNa cotransportNBCeNBCnNCBTSLC4SLC4 structureSodium

Identifiers

PMID38536494
PMCPMC11338471
OpenAlexW4393231657

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.