Evidence map›Paper›PMID 38536659›Full record

ArticleJournal of physiology and biochemistry2024

Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.

Huan Zhang, Shanshan Hu, Jaceline Gislaine Pires Sanches, Yizi Li, Yuanyi Wei, Chunwen Pu, Jun Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of physiology and biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Huan Zhang *Department of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Shanshan Hu *Department of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Jaceline Gislaine Pires SanchesDepartment of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yizi LiDepartment of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China.
Yuanyi WeiKey Laboratory of Tumor Metastasis of Liaoning Province, Dalian, 116044, China.
Chunwen PuDalian Public Health Clinical Center, Dalian Municipal Research Institute for Public Health, Dalian, 116031, China. 2295050337@qq.com.
Jun ZhangDepartment of Pathology and Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian, 116044, China. DLCOM@126.com.ORCID http://orcid.org/0000-0002-9765-5294
Dalian Medical University · CNDalian Municipal Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly vascularized tumor, one of the most common and lethal cancer-related tumor deaths worldwide, with cell proliferation playing a key role. In this study our western blot results and data from TAGC demonstrate a strong association between Sorcin (SRI) overexpression and poor outcomes in HCC. Moreover, SRI overexpression was remarkably effective in promoting proliferation in vitro and increasing tumor growth in vivo, which were attenuated by knocking down SRI. Mechanistically, SRI regulated vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor B (VEGFB) through PI3K/Akt/FOXO1 signal pathway. Overall, our study indicates that SRI stimulates HCC growth by controlling VEGFA/B, which presents a fresh insight into the pathogenesis of hepatocarcinogenesis and a new therapeutic target for HCC.

Indexed as

Calcium-Binding ProteinsCarcinoma, HepatocellularCell ProliferationLiver NeoplasmsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor BAnimalsCell Line, TumorForkhead Box Protein O1Gene Expression Regulation, NeoplasticHep G2 CellsHumansMiceMice, Inbred BALB CMice, NudePhosphatidylinositol 3-KinasesCalcium-Binding ProteinsForkhead Box Protein O1FOXO1 protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSRI protein, humanVascular Endothelial Growth Factor AVascular Endothelial Growth Factor BVEGFA protein, humanVEGFB protein, humanHepatocellular carcinomaProliferationSRIVEGFAVEGFB

Identifiers

PMID38536659
OpenAlexW4393232012

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.