ArticleeLife2024
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release.
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Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
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Who cites it
25 citing papers in PubMed, 14 citations in OpenAlex.
- Alternative splicing of synaptotagmin 7 regulates oligomerization and short-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Reorganization of synchronous and asynchronous release in developing hippocampal autaptic neurons of mice.Physiological reports · 2026Article
- Increased CA3 burst activity inbioRxiv : the preprint server for biology · 2026Article
- Acute ethanol inhibits asynchronous glutamate release from mouse basolateral amygdala synapses.Neuropharmacology · 2026Article
- Review
- Kv2-VAP interactions enhance presynaptic ER and mitochondrial calcium influx and the mobilization of vesicles from the reserve pool.bioRxiv : the preprint server for biology · 2026Article
- SNAP-25 disease variants affect synaptic transmission by destabilizing SNARE complexes within a multimeric SNARE ring.Cell reports · 2026Article
- Impact of distinct neurotransmitter release modes on neuronal signaling.Molecular psychiatry · 2026Review
- The Calcium-Binding Protein S100A10 (p11) Is Required for Normal Motor Performance by Regulating Vesicle Dynamics at Excitatory Synapses.Acta physiologica (Oxford, England) · 2026Article
- Synaptotagmin-7 drives stress-induced cardiomyocyte necroptosis via the p53-Bak-mPTP axis.Theranostics · 2026Article
- Independently engaging protein tethers of different length enhance synaptic vesicle trafficking to the plasma membrane.The Journal of physiology · 2025Article
- Cryptic splicing in synaptic and membrane excitability genes links TDP-43 loss to neuronal dysfunction.bioRxiv : the preprint server for biology · 2025Article
- Synaptic Vesicle Recycling at the Developing Presynapse.Journal of neurochemistry · 2025Review
- Using multiscale molecular dynamics simulations to explore the fusion machinery underlying neurotransmitter release.Quarterly reviews of biophysics · 2025Review
- Minimal presynaptic protein machinery governing diverse kinetics of calcium-evoked neurotransmitter release.Nature communications · 2024Article
- Synaptotagmins 3 and 7 mediate the majority of asynchronous release from synapses in the cerebellum and hippocampus.Cell reports · 2024Article
- Disease-linked mutations in Munc18-1 deplete synaptic Doc2.Brain : a journal of neurology · 2024Article
- A minimal presynaptic protein machinery mediating synchronous and asynchronous exocytosis and short-term plasticity.bioRxiv : the preprint server for biology · 2024Article
- Article
- Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Zhenyong Wu *Department of Neuroscience, University of Wisconsin-Madison, Madison, United States.
Grant F Kusick *Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-4312-3495
Manon M M BernsDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2998-4202
Sumana RaychaudhuriDepartment of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, United States.
Kie ItohDepartment of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0003-4379-400X
Alexander M WalterDepartment of Neuroscience, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5646-4750
Edwin R ChapmanDepartment of Neuroscience, University of Wisconsin-Madison, Madison, United States.ORCID https://orcid.org/0000-0001-9787-8140
Shigeki WatanabeDepartment of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0001-7580-8141
Johns Hopkins University · USHoward Hughes Medical Institute · USUniversity of Copenhagen · DK
Funding
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1MSynaptotagmin C2B Domain as a Ca2+ Sensing ModuleR01MH061876 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Edwin R Chapman · 2002 to 2026
$7.7MStructure and dynamics of exocytotic fusion poresR35NS097362 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI CHAPMAN, EDWIN R · 2017 to 2024
$4.6MUltrafast membrane trafficking at synapsesR35NS132153 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Shigeki Watanabe · 2023 to 2026
$4.1MReviving electron microscopy for synaptic cell biologyDP2NS111133 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2018
$2.5MSpatial and molecular determinants of fusion probability and timingR01NS105810 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WATANABE, SHIGEKI · 2018 to 2022
$1.8MRequest for Leica High-pressure Freezer and Automated Freeze-substitution SystemS10RR026445 · NCRR · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2010 to 2010
$273kHoward Hughes Medical Institute InvestigatorNCRR NIH HHS S10 RR026445NIGMS NIH HHS T32 GM007445NIH HHS R01 MH061876NIH HHS R35 NS097362NIH HHS S10RR026445NIH HHS T32 GM007445NIMH NIH HHS R01 MH061876NINDS NIH HHS DP2 NS111133NINDS NIH HHS NS105810NINDS NIH HHS NS111133-01NINDS NIH HHS NS132153-01NINDS NIH HHS R01 NS105810NINDS NIH HHS R35 NS097362NINDS NIH HHS R35 NS132153
Abstract
Despite decades of intense study, the molecular basis of asynchronous neurotransmitter release remains enigmatic. Synaptotagmin (syt) 7 and Doc2 have both been proposed as Ca
Indexed as
SynapsesSynaptic VesiclesSynaptotagminsAction PotentialsAnimalsCalciumCalcium-Binding ProteinsExocytosisMiceNerve Tissue ProteinsNeurotransmitter AgentsSynaptic TransmissionSynaptotagmin ICalciumCalcium-Binding ProteinsDoc2a protein, mouseNerve Tissue ProteinsNeurotransmitter AgentsSynaptotagmin ISynaptotagminsSyt7 protein, mouseasynchronous releasecell biologyiGluSnFRmouseneuroscienceshort-term plasticitysynaptic vesicle dockingsynaptotagminzap-and-freeze
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.