ArticleNature2024
A brainstem-hypothalamus neuronal circuit reduces feeding upon heat exposure.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 25 citations in OpenAlex.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells.Cell stem cell · 2026Article
- Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026Review
- Cell-type-specific architecture of the hypothalamus in a socially plastic vertebrate.bioRxiv : the preprint server for biology · 2026Article
- A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation.Nature communications · 2026Article
- Neurovascular plasticity as a modulator of hypothalamic function.Reviews in endocrine & metabolic disorders · 2026Review
- Exercise as a multiscale recalibration of stress-related homeostatic balance.Frontiers in neuroscience · 2026Review
- Comparative effects of β-glucan and mannan oligosaccharides on heat stress-induced inflammation: associations with gut barrier integrity and intestinal microbiota in mice.Frontiers in nutrition · 2026Article
- Region-Specific Adult Neural Stem Cell Niches of the Mediobasal Hypothalamus and Medulla Oblongata.Stem cell reviews and reports · 2026Review
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- Changes in physiological parameters and thermal comfort when wearing protective clothing in long-range aeromedical evacuation: a prospective, non-blinded, two-stage crossover self-controlled study.Journal of physiological anthropology · 2025Article
- Luminescence-enabled three-dimensional temperature bioimaging.Nature communications · 2025Article
- The ARCNature communications · 2025Article
- Molecular and cellular mechanisms of itch sensation and the anti-itch drug targets.Acta pharmacologica Sinica · 2025Review
- Advances in appetite regulation by the arcuate nucleus.Nature reviews. Endocrinology · 2025Article
- Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone-Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation.Research (Washington, D.C.) · 2025Article
- Hypothalamic neural circuits regulating energy expenditure.Vitamins and hormones · 2025Review
- Hypothalamic neuronal-glial crosstalk in metabolic disease.npj metabolic health and disease · 2024Review
- Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer's disease.Cell & bioscience · 2024Article
- Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 7 institutions in 6 countries.
Marco BeneventoDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3555-894X
Alán AlpárDepartment of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, Hungary.
Anna GundackerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Leila AfjehiProgramme Proteomics, Paracelsus Medizinische Privatuniversität, Salzburg, Austria.
Kira BaluevaInstitute of Physiology, Christian Albrechts University, Kiel, Germany.
Zsofia HevesiDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
János HanicsDepartment of Anatomy, Histology, and Embryology, Semmelweis University, Budapest, Hungary.
Sabah RehmanDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Daniela D PollakDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9584-6257
Gert LubecProgramme Proteomics, Paracelsus Medizinische Privatuniversität, Salzburg, Austria.
Peer WulffInstitute of Physiology, Christian Albrechts University, Kiel, Germany.
Vincent PrevotUniversity of Lille, INSERM, CHU Lille, Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience and Cognition, UMR S1172, EGID, Lille, France.ORCID 0000-0001-7185-3615
Tamas L HorvathDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7522-4602
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria. Tibor.Harkany@meduniwien.ac.at.ORCID 0000-0002-6637-5900
Medical University of Vienna · ATChristian-Albrechts-Universität zu Kiel · DEParacelsus Medical University · ATSemmelweis University · HUInserm · FRKarolinska Institutet · SEYale University · US
Funding
The role of AgRP/Auga-ALK pathway in FGF21's brain action on agingP01AG051459 · NIA · YALE UNIVERSITY · PI VISHWA DEEP DIXIT · 2016 to 2026
$25.7MHypothalamus-driven anti-aging processes impact murine models of Alzheimer's DiseaseR01AG067329 · NIA · YALE UNIVERSITY · PI HORVATH, TAMAS L · 2020 to 2024
$3.2MThe role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposityR01DK126447 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L, RODEHEFFER, MATTHEW S · 2021 to 2024
$2.3MMCHergic control of feeding and energy balance in the LH areaR01DK120891 · NIDDK · YALE UNIVERSITY · PI GAO, XIAO-BING, HORVATH, TAMAS L · 2020 to 2023
$2.1MZona incerta GABA neurons modulate energy homeostasisR01DK115933 · NIDDK · YALE UNIVERSITY · PI GUNEL, MURAT · 2017 to 2021
$2.0MNIA NIH HHS P01 AG051459NIA NIH HHS R01 AG067329NIDDK NIH HHS R01 DK115933NIDDK NIH HHS R01 DK120891NIDDK NIH HHS R01 DK126447
Abstract
Empirical evidence suggests that heat exposure reduces food intake. However, the neurocircuit architecture and the signalling mechanisms that form an associative interface between sensory and metabolic modalities remain unknown, despite primary thermoceptive neurons in the pontine parabrachial nucleus becoming well characterized
Indexed as
Brain StemEpendymoglial CellsFeeding BehaviorHot TemperatureHypothalamusNeural PathwaysNeuronsAgouti-Related ProteinAnimalsArcuate Nucleus of HypothalamusDopamineEatingFemaleGlutamic AcidMaleMiceAgouti-Related ProteinDopamineFlt1 protein, mouseFos protein, mouseGlutamic AcidProto-Oncogene Proteins c-fosVAMP2 protein, humanVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-1Vesicle-Associated Membrane Protein 2
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.