Evidence map›Paper›PMID 38538927›Full record

ArticleLung2024

Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia.

Michael Frazure, Clinton L Greene, Kimberly E Iceman, Dena R Howland, Teresa Pitts

Open access · greenAbstract read
In one paragraph

Article in Lung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Efficacy of transoral partial laryngectomy with zeitels and holmium laser in 42 glottic cancers.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Serotonin therapies for opioid-induced disordered swallow and respiratory depression.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael FrazureDepartment of Physiology, School of Medicine, University of Louisville, Louisville, KY, USA.
Clinton L GreeneDepartment of Speech Language and Hearing Sciences and Dalton Cardiovascular Center, University of Missouri, 701 S Fifth St, Columbia, MO, 65203, USA.
Kimberly E IcemanDepartment of Speech Language and Hearing Sciences and Dalton Cardiovascular Center, University of Missouri, 701 S Fifth St, Columbia, MO, 65203, USA.
Dena R HowlandDepartment of Neurological Surgery and Kentucky Spinal Cord Injury Research Center, College of Medicine, University of Louisville, Louisville, KY, USA.
Teresa PittsDepartment of Speech Language and Hearing Sciences and Dalton Cardiovascular Center, University of Missouri, 701 S Fifth St, Columbia, MO, 65203, USA. t.pitts@health.missouri.edu.ORCID 0000-0001-9448-2175
University of Missouri · USUniversity of Louisville · US

Funding

Altered Motor Function & Force Feedback After Spinal Cord InjuryR01NS097781 · NINDS · UNIVERSITY OF LOUISVILLE · PI HOWLAND, DENA R., NICHOLS, T. RICHARD · 2017 to 2021
$3.0M
Central and Peripheral Regulation of Laryngeal AdductionR01HL163008 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, PITTS, TERESA G · 2022 to 2025
$2.8M
Influence of Opioids on the Brainstem Respiratory NetworkR01HL155721 · NHLBI · UNIVERSITY OF FLORIDA · PI BOLSER, DONALD C, MORRIS, KENDALL FRANCIS · 2021 to 2024
$2.7M
Regulation of swallow and the effects of high cervical spinal cord injuryR01NS110169 · NINDS · UNIVERSITY OF LOUISVILLE · PI PITTS, TERESA G · 2019 to 2023
$1.7M
Delineating impacts of gestational opioid exposure on central swallow networks.R21HD110951 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI PITTS, TERESA G · 2023 to 2024
$411k
NHLBI NIH HHS R01 HL155721NHLBI NIH HHS R01 HL163008NICHD NIH HHS R21 HD110951NIH HHS NS110169, HL155721, HL163008, HD110951, OT20D001983NIH HHS NS110169, NS097781NINDS NIH HHS R01 NS097781NINDS NIH HHS R01 NS110169
6 · The paper itself

Abstract

purposePostoperative pneumonia remains a common complication of surgery, despite increased attention. The purpose of our study was to determine the effects of routine surgery and post-surgical opioid administration on airway protection risk.

methodsEight healthy adult cats were evaluated to determine changes in airway protection status and for evidence of dysphagia in two experiments. (1) In four female cats, airway protection status was tracked following routine abdominal surgery (spay surgery) plus low-dose opioid administration (buprenorphine 0.015 mg/kg, IM, q8-12 h; n = 5). (2) Using a cross-over design, four naive cats (2 male, 2 female) were treated with moderate-dose (0.02 mg/kg) or high-dose (0.04 mg/kg) buprenorphine (IM, q8-12 h; n = 5).

resultsAirway protection was significantly affected in both experiments, but the most severe deficits occurred post-surgically as 75% of the animals exhibited silent aspiration.

conclusionOropharyngeal swallow is impaired by the partial mu-opioid receptor agonist buprenorphine, most remarkably in the postoperative setting. These findings have implications for the prevention and management of aspiration pneumonia in vulnerable populations.

Indexed as

Analgesics, OpioidCat DiseasesDeglutition DisordersPneumoniaAnimalsBuprenorphineCatsCross-Over StudiesFemaleMaleAnalgesics, OpioidBuprenorphineAspirationDysphagiaOpioidPneumoniaPostoperativeSwallow

Identifiers

PMID38538927
PMCPMC11135177
OpenAlexW4393217747

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.