Evidence mapPaperPMID 38539349Full record

ArticleChildren (Basel, Switzerland)2024

New Clinical Markers of Oxidized Lipid-Associated Protein Damage in Children and Adolescents with Obesity.

Eirini Kostopoulou, Athina Varemmenou, Electra Kalaitzopoulou, Polyxeni Papadea, Marianna Skipitari, Andrea Paola Rojas Gil, Bessie E Spiliotis, Sotirios Fouzas, Christos D Georgiou

Abstract read
In one paragraph

Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eirini KostopoulouDepartment of Pediatrics, School of Medicine, University of Patras, 26500 Patras, Greece.ORCID 0000-0002-7051-7537
Athina VaremmenouDepartment of Medicine, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-6277-5894
Electra KalaitzopoulouDepartment of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-7486-910X
Polyxeni PapadeaDepartment of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0002-5131-8196
Marianna SkipitariDepartment of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0001-5077-1418
Andrea Paola Rojas GilLaboratory of Basic Health Sciences, Department of Nursing, Faculty of Health Sciences, University of Peloponnese, 22100 Tripoli, Greece.ORCID 0000-0002-9812-2131
Bessie E SpiliotisDepartment of Pediatrics, School of Medicine, University of Patras, 26500 Patras, Greece.ORCID 0000-0001-7922-4012
Sotirios FouzasDepartment of Pediatrics, School of Medicine, University of Patras, 26500 Patras, Greece.ORCID 0000-0001-7617-9076
Christos D GeorgiouDepartment of Biology, University of Patras, 26504 Patras, Greece.ORCID 0000-0001-9707-0109

Funding

IKY Scholarship Programme for PhD candidates in the Greek Universities 2022-050-0502-52508, 2022-050-0502-52518
6 · The paper itself

Abstract

Obesity in children and adolescents has been associated with oxidative stress (OS). The lipid hydroperoxides (LOOH) and the malondialdehyde (MDA) and thiobarbituric reactive substances (TBARS) that oxidatively modify proteins (Pr) (i.e., PrMDA and PrTBARS, respectively) represent markers of OS-associated lipid peroxidation. We aimed to assess OS in children and adolescents with obesity using-for the first time-markers involved in the early and late lipid oxidation process. LOOH, PrMDA, and PrTBARS were investigated in 41 children and adolescents with obesity and 31 controls. Obesity was defined as BMI > 95% for age and sex. The PrMDA/PrTBARS pair, which reflects a late peroxidation stage, was found to be significantly high (39%/180%) in children and adolescents with obesity compared to controls (

Indexed as

childrenLOOHobesityoxidative stressPrMDAPrTBARS

Identifiers

PMID38539349
PMCPMC10969367

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.