Evidence map›Paper›PMID 38539462›Full record

ArticleCancers2024

Multimodal, Technology-Assisted Intervention for the Management of Menopause after Cancer Improves Cancer-Related Quality of Life-Results from the Menopause after Cancer (Mac) Study.

Fionán Donohoe, Yvonne O'Meara, Aidin Roberts, Louise Comerford, Ivaila Valcheva, Una Kearns, Marie Galligan, Michaela J Higgins, Alasdair L Henry, Catherine M Kelly and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04766229 (A Multimodal Technology-assisted Intervention for the Management of Menopause After Cancer), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04766229 phase2completednot on this map

A Multimodal Technology-assisted Intervention for the Management of Menopause After Cancer: The Menopause After Cancer Study

TypeinterventionalSponsorUniversity College DublinRan2021 to 2022Enrolled205ConditionsMenopause, Cancer, InsomniaArmsCitalopram +/- Gabapentin + Sleepio + support person
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Fionán DonohoeUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.ORCID 0000-0003-2632-951X
Yvonne O'MearaUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.
Aidin RobertsUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.
Louise ComerfordUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.
Ivaila ValchevaUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.ORCID 0000-0002-2390-0138
Una KearnsmyPatientSpace Ltd., K36 A022 Dublin, Ireland.
Marie GalliganClinical Research Centre, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.
Michaela J HigginsDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, D04 T6F4 Dublin, Ireland.ORCID 0000-0002-9065-8652
Alasdair L HenryBig Health Ltd., London WC1H 9LT, UK.
Catherine M KellyDepartment of Medical Oncology, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.
Janice M WalsheDepartment of Medical Oncology, St. Vincent's University Hospital, Elm Park, D04 T6F4 Dublin, Ireland.ORCID 0009-0002-1938-8730
Martha HickeyDepartment of Obstetrics and Gynaecology, University of Melbourne and The Royal Women's Hospital, Parkville, VIC 3052, Australia.
Donal J BrennanUCD Gynaecological Oncology Group, UCD School of Medicine, Mater Misericordiae University Hospital, Eccles Street, D07 AX57 Dublin, Ireland.ORCID 0000-0002-6747-3342
Mater Misericordiae University Hospital · IESt. Vincent's University Hospital · IEHinge Health · USRoyal Women's Hospital · AUUniversity College Dublin · IE

Funding

Irish Cancer Society WHIBRE20
6 · The paper itself

Abstract

backgroundVasomotor symptoms (VMSs) associated with menopause represent a significant challenge for many patients after cancer treatment, particularly if conventional menopausal hormone therapy (MHT) is contraindicated.

methodsThe Menopause after Cancer (MAC) Study (NCT04766229) was a single-arm phase II trial examining the impact of a composite intervention consisting of (1) the use of non-hormonal pharmacotherapy to manage VMS, (2) digital cognitive behavioral therapy for insomnia (dCBT-I) using Sleepio (Big Health), (3) self-management strategies for VMS delivered via the myPatientSpace mobile application and (4) nomination of an additional support person/partner on quality of life (QoL) in women with moderate-to-severe VMS after cancer. The primary outcome was a change in cancer-specific global QoL assessed by the EORTC QLC C-30 v3 at 6 months. Secondary outcomes included the frequency of VMS, the bother/interference of VMS and insomnia symptoms.

resultsIn total, 204 women (82% previous breast cancer) with a median age of 49 years (range 28-66) were recruited. A total of 120 women completed the protocol. Global QoL scores increased from 62.2 (95%CI 58.6-65.4) to 70.4 (95%CI 67.1-73.8) at 6 months (

conclusionsA targeted composite intervention improves the quality of life for cancer patients with frequent and bothersome vasomotor symptoms with additional benefits on frequency, the bother/interference of VMS and insomnia symptoms.

Indexed as

insomniamenopausequality of lifesurvivorship

Identifiers

PMID38539462
PMCPMC10969475
OpenAlexW4392697021

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.