Evidence map›Paper›PMID 38539614›Full record

ReviewBrain sciences2024

The Role of Lurasidone in Managing Depressive Symptoms in People with Schizophrenia: A Review.

Andrea Fiorillo, Gaia Sampogna, Umberto Albert, Emi Bondi, Serafino De Giorgi, Andrea Fagiolini, Maurizio Pompili, Gianluca Serafini, Umberto Volpe, Antonio Vita

Open access · goldAbstract readReview
In one paragraph

Review in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Andrea FiorilloDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Gaia SampognaDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Umberto AlbertDepartment of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0001-9781-4219
Emi BondiDepartment of Mental Health and Addictions, ASST Papa Giovanni XXIII, 24121 Bergamo, Italy.
Serafino De GiorgiDepartment of Mental Health, ASL Lecce, 73100 Lecce, Italy.
Andrea FagioliniDivision of Psychiatry, University of Siena, 53100 Siena, Italy.
Maurizio PompiliDepartment of Neurosciences, Mental Health and Sensory Organs, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa, 1035, 00189 Rome, Italy.ORCID 0000-0003-1886-4977
Gianluca SerafiniSection of Psychiatry, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16131 Genoa, Italy.ORCID 0000-0002-6631-856X
Umberto VolpeClinical Psychiatry Unit, Department of Clinical Neurosciences, Università Politecnica delle Marche, 60126 Ancona, Italy.
Antonio VitaDepartment of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy.
University of Campania "Luigi Vanvitelli" · ITIstituto Nazionale di Fisica Nucleare, Sezione di Lecce · ITMarche Polytechnic University · ITOspedale Papa Giovanni XXIII · ITOspedale Policlinico San Martino · ITSapienza University of Rome · ITUniversity of Brescia · ITUniversity of Siena · ITUniversity of Trieste · IT

Funding

Angelini Pharma (Italy) 2024
6 · The paper itself

Abstract

backgroundSchizophrenia is a severe mental disorder characterized by positive, negative, affective, and cognitive symptoms. Affective symptoms in patients with schizophrenia have traditionally been overlooked or even neglected because they are not considered as fundamental as positive and negative symptoms in the choice of medication.

methodsThis paper aims to systematically evaluate the efficacy and safety of lurasidone in the treatment of depressive symptoms of schizophrenia.

resultsLurasidone appears to be particularly effective on the depressive symptomatology of schizophrenia while also alleviating the positive and negative symptoms associated with the illness.

conclusionsThe efficacy of lurasidone in treating patients with first-episode psychosis who present with predominant depressive symptoms suggests that this medication may be a valuable treatment option not only for established cases of schizophrenia but also for individuals in the early stages of the illness. The good tolerability of lurasidone is an important factor that may positively influence treatment decisions.

Indexed as

antipsychoticdepressive symptomslurasidonepersonalized treatmentschizophrenia

Identifiers

PMID38539614
PMCPMC10968750
OpenAlexW4392233977

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.