Evidence map›Paper›PMID 38539894›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Pharmacologic Ascorbate Radiosensitizes Pancreatic Cancer but Radioprotects Normal Tissue: The Role of Oxidative Stress-Induced Lipid Peroxidation.

Gloria Y Chen, Brianne R O'Leary, Juan Du, Rory S Carroll, Garett J Steers, Garry R Buettner, Joseph J Cullen

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  7. Balanced Duality: HInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gloria Y ChenDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.
Brianne R O'LearyDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-7431-1141
Juan DuDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.
Rory S CarrollDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.
Garett J SteersDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9210-9828
Garry R BuettnerFree Radical and Radiation Biology Division, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-5594-1903
Joseph J CullenDepartments of Surgery, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-2222-1328
University of Iowa · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
NCI NIH HHS P30 CA086862NIEHS NIH HHS P30 ES005605NIH HHS PO1 217797NIH HHS T32 CA78586
6 · The paper itself

Abstract

The toxicity of ionizing radiation limits its effectiveness in the treatment of pancreatic ductal adenocarcinoma. Pharmacologic ascorbate (P-AscH

Indexed as

ascorbatelipid peroxidationpancreatic cancerradioprotection

Identifiers

PMID38539894
PMCPMC10967795
OpenAlexW4392919405

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.