Evidence map›Paper›PMID 38540095›Full record

ReviewBiomedicines2024

Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review.

Iñaki Ortego-Isasa, Juan Francisco Ortega-Morán, Héctor Lozano, Thomas Stieglitz, Francisco M Sánchez-Margallo, Jesús Usón-Gargallo, J Blas Pagador, Ander Ramos-Murguialday

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Iñaki Ortego-IsasaTECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, Spain.ORCID 0000-0002-2178-4647
Juan Francisco Ortega-MoránJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, Spain.ORCID 0000-0002-0287-5498
Héctor LozanoTECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, Spain.
Thomas StieglitzLaboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK and BrainLinks-BrainTools Center, University of Freiburg, 79110 Freiburg, Germany.ORCID 0000-0002-7349-4254
Francisco M Sánchez-MargalloJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, Spain.ORCID 0000-0003-2138-988X
Jesús Usón-GargalloJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, Spain.
J Blas PagadorJesús Usón Minimally Invasive Surgery Centre, 10071 Cáceres, Spain.ORCID 0000-0002-4382-5075
Ander Ramos-MurguialdayTECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, Spain.
Tecnalia · ESCentro de Cirugía de Mínima Invasión Jesús Usón · ESInstituto de Salud Carlos III · ESUniversity of Freiburg · DE

Funding

Diputación Foral de Gipuzkoa Red Guipuzcoana de Ciencia, Tecnología e Innovación" program reference 54/2019.European Union European Regional Development Fund. BBB012Government of Extremadura Consejería de Educación, Ciencia y Formación Profesional
6 · The paper itself

Abstract

Chronic constipation affects around 20% of the population and there is no efficient solution. This perspective review explores the potential of colonic electric stimulation (CES) using neural implants and methods of bioelectronic medicine as a therapeutic way to treat chronic constipation. The review covers the neurophysiology of colonic peristaltic function, the pathophysiology of chronic constipation, the technical aspects of CES, including stimulation parameters, electrode placement, and neuromodulation target selection, as well as a comprehensive analysis of various animal models highlighting their advantages and limitations in elucidating the mechanistic insights and translational relevance for CES. Finally, the main challenges and trends in CES are discussed.

Indexed as

bioelectronicscolonic electric stimulation (CES)constipationneural implant

Identifiers

PMID38540095
PMCPMC10967790
OpenAlexW4391997062

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.