Evidence map›Paper›PMID 38540201›Full record

ArticleBiomedicines2024

Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model.

Maria Siemionow, Katarzyna Budzynska, Kristina Zalants, Paulina Langa, Sonia Brodowska, Krzysztof Siemionow, Ahlke Heydemann

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
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  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maria SiemionowDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0001-6372-6122
Katarzyna BudzynskaDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0009-0001-9150-9974
Kristina ZalantsDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-1914-9812
Paulina LangaDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Sonia BrodowskaDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Krzysztof SiemionowDepartment of Orthopaedics, University of Illinois at Chicago, Chicago, IL 60607, USA.
Ahlke HeydemannDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-2626-3787
University of Illinois Chicago · USPoznan University of Medical Sciences · PL

Funding

University of Illinois Chancellor's Innovation Fund (CIF) Proof of Concept Award 2017
6 · The paper itself

Abstract

Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutation in the dystrophin gene. Currently there is no cure for DMD. We introduced a novel human Dystrophin Expressing Chimeric (DEC) cell therapy of myoblast origin and confirmed the safety and efficacy of DEC in the

Indexed as

cardiac and skeletal muscle morphologyDEC therapyDuchenne Muscular Dystrophy (DMD)Dystrophin Expressing Chimeric (DEC) cellsmdx miceminimal Feret’s fiber diametermuscle fibrosisstem cellssystemic-intraosseous administration

Identifiers

PMID38540201
PMCPMC10968566
OpenAlexW4392506344

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.