Evidence map›Paper›PMID 38541714›Full record

ArticleLife (Basel, Switzerland)2024

Lifestyle-Driven Variations in Nutrimiromic MicroRNA Expression Patterns across and beyond Genders.

Angelika Pointner, Ulrike D B Krammer, Elena Tomeva, Ulrich Magnet, Berit Hippe, Ursula Jacob, Alexander G Haslberger

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. The Conundrum of XenomiRs and Human Health.Advances in nutrition (Bethesda, Md.) · 2025
    Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Angelika PointnerDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0009-0009-9383-3207
Ulrike D B KrammerDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6053-9604
Elena TomevaHealthBioCare GmbH, 1090 Vienna, Austria.ORCID 0000-0002-5990-726X
Ulrich MagnetHealthBioCare GmbH, 1090 Vienna, Austria.
Berit HippeDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-7830-8812
Ursula JacobDayclinic Dr. Jacob, 81675 Munich, Germany.
Alexander G HaslbergerDepartment of Nutritional Sciences, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9699-537X
University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of diet and lifestyle in maintaining overall health has long been recognised. MicroRNAs (miRNAs) have emerged as key players in the intricate interplay between health and disease. This study, including 305 participants, examined the role of miRNAs from capillary blood as indicators of individual physiological characteristics, diet, and lifestyle influences. Key findings include specific miRNAs associated with inflammatory processes and dietary patterns. Notably, miR-155 was associated with subjects with metabolic diseases and upregulated in age. Additionally, the study revealed diet-related miRNA expressions: high consumption of vegetables, fruits, and whole grains correlated with increased levels of miR-let-7a and miR-328, both implicated in anti-inflammatory pathways, and decreased expression of pro-inflammatory miR-21. In the context of smoking, we found a significant decrease in miRNA-142, known for its downregulation in lung cancer. We observed a sex-biased expression of various miRNAs with significant upregulation of miR-151a in females and a higher expression of miR-155 in ageing females, representing a possible mechanism for the increased susceptibility to autoimmune diseases. In conclusion, the study underscores the significant influence of lifestyle, nutrition, and sex on miRNA profiles. Circulating miRNAs demonstrate significant potential as biomarkers in personalized medicine, highlighting their utility in tailoring healthcare to individual needs.

Indexed as

biomarkerepigeneticinflammationlifestylemiRNAsnutrimiromicsnutritionprecision nutritionsmoking

Identifiers

PMID38541714
PMCPMC10971939
OpenAlexW4392857985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.