Evidence map›Paper›PMID 38542176›Full record

ArticleInternational journal of molecular sciences2024

Loss of ERβ Disrupts Gene Regulation in Primordial and Primary Follicles.

Eun Bee Lee, V Praveen Chakravarthi, Ryan Mohamadi, Vinesh Dahiya, Kevin Vo, Anamika Ratri, Patrick E Fields, Courtney A Marsh, M A Karim Rumi

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Eun Bee LeeDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
V Praveen ChakravarthiDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.ORCID 0000-0002-7610-4610
Ryan MohamadiDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
Vinesh DahiyaDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
Kevin VoDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
Anamika RatriDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
Patrick E FieldsDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
Courtney A MarshDepartment of Obstetrics and Gynecology, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.ORCID 0000-0001-8586-8172
M A Karim RumiDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center (KUMC), Kansas City, KS 66160, USA.
University of Kansas Medical Center · US

Funding

Oocyte stage-specific role of ERβ in primordial follicle activationR21HD105095 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI RUMI, MOHAMMAD A.K. · 2021 to 2022
$425k
Eunice Kennedy Shriver National Institute of Child Health and Human Development NIH R21 HD105095NICHD NIH HHS R21 HD105095
6 · The paper itself

Abstract

Loss of ERβ increases primordial follicle growth activation (PFGA), leading to premature ovarian follicle reserve depletion. We determined the expression and gene regulatory functions of ERβ in dormant primordial follicles (PdFs) and activated primary follicles (PrFs) using mouse models. PdFs and PrFs were isolated from 3-week-old

Indexed as

Estrogen Receptor betaOvarian FollicleAnimalsFemaleGene Expression RegulationMiceMice, KnockoutOvaryTranscriptomeEstrogen Receptor betaestrogen receptor βprimary folliclesprimordial follicle growth activationprimordial folliclestranscriptome analysis

Identifiers

PMID38542176
PMCPMC10970686
OpenAlexW4392662328

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.