Autoantibodies-Abzymes with Phosphatase Activity in Experimental Autoimmune Encephalomyelitis Mice.

Andrey E Urusov, Kseniya S Aulova, Georgy A Nevinsky

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.4field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Andrey E UrusovInstitute of Chemical Biology and Fundamental Medicine, SB of the Russian Academy of Sciences, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.

Kseniya S AulovaInstitute of Chemical Biology and Fundamental Medicine, SB of the Russian Academy of Sciences, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.ORCID 0000-0001-6972-9068

Georgy A NevinskyInstitute of Chemical Biology and Fundamental Medicine, SB of the Russian Academy of Sciences, Lavrentiev Ave., 8, 630090 Novosibirsk, Russia.ORCID 0000-0002-4988-8923

Novosibirsk State University · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

Russian Science Foundation (Grant number 22-15-00103

6 · The paper itself

Abstract

The exact mechanisms of MS (multiple sclerosis) evolution are still unknown. However, the development of EAE (experimental autoimmune encephalomyelitis simulating human MS) in C57BL/6 mice occurs due to the violation of bone marrow hematopoietic stem cell differentiation profiles, leading to the production of toxic for human autoantibody splitting MBP (myelin basic protein), MOG (mouse oligodendrocyte glycoprotein), five histones, DNA, and RNA. Here, we first analyzed the changes in the relative phosphatase activity of IgGs from C57BL/6 mice blood over time, corresponding to three stages of EAE: onset, acute, and remission. Antibodies have been shown to catalyze the hydrolysis of

Indexed as

Antibodies, CatalyticEncephalomyelitis, Autoimmune, ExperimentalAnimalsAutoantibodiesDNAHistonesHumansMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinPhosphoric Monoester HydrolasesAntibodies, CatalyticAutoantibodiesDNAHistonesMyelin-Oligodendrocyte GlycoproteinPhosphoric Monoester HydrolasesC57BL/6 micecatalytic antibodiesexperimental autoimmune encephalomyelitis (EAE) modelphosphatase activity

Identifiers

PMID38543019

DOI10.3390/molecules29061382

PMCPMC10975087

OpenAlexW4392996117

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.