Evidence map›Paper›PMID 38545661›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats.

Milena Samora, Yu Huo, Kimber L Stanhope, Peter J Havel, Marc P Kaufman, Michelle L Harrison, Audrey J Stone

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Altered Blood Pressure Reflexes in Women With Endometriosis.Hypertension (Dallas, Tex. : 1979) · 2025
    Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Milena SamoraDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0001-6348-1786
Yu HuoDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States.
Kimber L StanhopeDepartment of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California Davis, Davis, California, United States.
Peter J HavelDepartment of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition, University of California Davis, Davis, California, United States.
Marc P KaufmanHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, United States.
Michelle L HarrisonDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0001-9205-1961
Audrey J StoneDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, United States.ORCID 0000-0002-0081-0244
The University of Texas at Austin · USUniversity of California, Davis · USPenn State Milton S. Hershey Medical Center · US

Funding

Temporal effects of inflammation on the autonomic control of circulation during exercise in type 2 diabetic ratsR01HL144723 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI STONE, AUDREY J · 2019 to 2023
$2.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL-144723NHLBI NIH HHS R01 HL144723
6 · The paper itself

Abstract

Cyclooxygenase (COX) products of arachidonic acid metabolism, specifically prostaglandins, play a role in evoking and transmitting the exercise pressor reflex in health and disease. Individuals with type 2 diabetes mellitus (T2DM) have an exaggerated exercise pressor reflex; however, the mechanisms for this exaggerated reflex are not fully understood. We aimed to determine the role played by COX products in the exaggerated exercise pressor reflex in T2DM rats. The exercise pressor reflex was evoked by static muscle contraction in unanesthetized, decerebrate, male, adult University of California Davis (UCD)-T2DM (

Indexed as

Diabetes Mellitus, Type 2Muscle ContractionMuscle, SkeletalReflexAnimalsArterial PressureBlood PressureCyclooxygenase InhibitorsHeart RateIndomethacinMalePhysical Conditioning, AnimalProstaglandin-Endoperoxide SynthasesRatsRats, Sprague-DawleyCyclooxygenase InhibitorsIndomethacinProstaglandin-Endoperoxide Synthasesautonomic control of circulationblood pressurecyclooxygenase activityindomethacintype III/IV afferent fibers

Identifiers

PMID38545661
PMCPMC11368523
OpenAlexW4393268491

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.