Evidence map›Paper›PMID 38546821›Full record

Trial reportDiabetologia2024

Integration of a fasting-mimicking diet programme in primary care for type 2 diabetes reduces the need for medication and improves glycaemic control: a 12-month randomised controlled trial.

Elske L van den Burg, Marjolein P Schoonakker, Petra G van Peet, Elske M van den Akker-van Marle, Hildo J Lamb, Valter D Longo, Mattijs E Numans, Hanno Pijl

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03811587 (Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03811587 nacompletednot on this map

Clinical Feasibility and Efficacy of Intermittent Use of a Fasting Mimicking Diet in the Treatment of Type 2 Diabetes

TypeinterventionalSponsorLeiden University Medical CenterRan2018 to 2021Enrolled100ConditionsDiabetes Mellitus, Type 2ArmsFasting Mimicking diet
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Elske L van den BurgDepartment of Public Health and Primary Care, Leiden University Medical Centre (LUMC), Leiden, the Netherlands. e.l.van_den_burg@lumc.nl.ORCID http://orcid.org/0000-0002-3149-5304
Marjolein P SchoonakkerDepartment of Public Health and Primary Care, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0003-1014-4190
Petra G van PeetDepartment of Public Health and Primary Care, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-7963-6575
Elske M van den Akker-van MarleDepartment of Biomedical Data Sciences, Medical Decision Making, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-5269-509X
Hildo J LambDepartment of Radiology, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-6969-2418
Valter D LongoLongevity Institute, Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-0946-7534
Mattijs E NumansDepartment of Public Health and Primary Care, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-0368-5426
Hanno PijlDepartment of Public Health and Primary Care, Leiden University Medical Centre (LUMC), Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3076-1551
Leiden University · NLLeiden University Medical Center · NLUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThe aim of this study was to evaluate the impact on metabolic control of periodic use of a 5-day fasting-mimicking diet (FMD) programme as an adjunct to usual care in people with type 2 diabetes under regular primary care surveillance.

methodsIn this randomised, controlled, assessor-blinded trial, people with type 2 diabetes using metformin as the only glucose-lowering drug and/or diet for glycaemic control were randomised to receive 5-day cycles of an FMD monthly as an adjunct to regular care by their general practitioner or to receive regular care only. The primary outcomes were changes in glucose-lowering medication (as reflected by the medication effect score) and HbA

resultsOne hundred individuals with type 2 diabetes, age 18-75 years, BMI ≥27 kg/m CONCLUSIONS/

interpretationIntegration of a monthly FMD programme in regular primary care for people with type 2 diabetes who use metformin as the only glucose-lowering drug and/or diet for glycaemic control reduces the need for glucose-lowering medication, improves HbA

trial registrationClinicalTrials.gov NCT03811587

fundingThe project was co-funded by Health~Holland, Top Sector Life Sciences & Health, the Dutch Diabetes Foundation and L-Nutra.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 2FastingGlycated HemoglobinGlycemic ControlHypoglycemic AgentsMetforminPrimary Health CareAdolescentAdultAgedFemaleHumansMaleMiddle AgedTreatment OutcomeBlood GlucoseGlycated HemoglobinHypoglycemic AgentsMetforminDietFasting-mimicking dietGlucose-lowering medicationHbA1c, LifestylePrimary careRandomised controlled trialTherapyType 2 diabetes

Identifiers

PMID38546821
PMCPMC11153305
OpenAlexW4393258687

What Socratic holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.