Evidence map›Paper›PMID 38547531›Full record

ArticleBiofabrication2024

Advancing preclinical drug evaluation through automated 3D imaging for high-throughput screening with kidney organoids.

Haruka Oishi, Nahid Tabibzadeh, Ryuji Morizane

Open access · hybridAbstract read
In one paragraph

Article in Biofabrication, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Deciphering the Impact of RAC1-SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  14. Organoids in disease modeling and regenerative medicine.Cellular and molecular life sciences : CMLS · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Haruka OishiNephrology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America.
Nahid TabibzadehNephrology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America.
Ryuji MorizaneNephrology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA, United States of America.ORCID 0000-0002-0377-5667
Harvard University · USMassachusetts General Hospital · US

Funding

Ex Vivo Generation of Functional Kidney Tissues for TransplantationUC2DK126023 · NIDDK · HARVARD UNIVERSITY · PI LEWIS, JENNIFER A. · 2020 to 2024
$4.0M
Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUH3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2019 to 2021
$3.3M
Recreating Kidney Organogenesis in vitro with Human Pluripotent Stem CellsDP2DK133821 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MORIZANE, RYUJI · 2019 to 2019
$2.5M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01DK127587 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2020 to 2022
$2.1M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01EB028899 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2019 to 2019
$748k
NCATS NIH HHS UH3 TR002155NIBIB NIH HHS U01 EB028899NIDDK NIH HHS DP2 DK133821NIDDK NIH HHS U01 DK127587NIDDK NIH HHS UC2 DK126023
6 · The paper itself

Abstract

High-throughput drug screening is crucial for advancing healthcare through drug discovery. However, a significant limitation arises from available

Indexed as

High-Throughput Screening AssaysImaging, Three-DimensionalCell DifferentiationCisplatinDrug Evaluation, PreclinicalEndothelial CellsHumansKidneyOrganoidsCisplatindrug discoverykidney organoidsnephrotoxicityscreening

Identifiers

PMID38547531
PMCPMC11304660
OpenAlexW4393280743

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.