Evidence mapPaperPMID 38548349Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Development of a CD163-Targeted PET Radiotracer That Images Resident Macrophages in Atherosclerosis.

Xiuli Zhang, Gyu Seong Heo, Alexandria Li, Divangana Lahad, Lisa Detering, Joan Tao, Xuefeng Gao, Xiaohui Zhang, Hannah Luehmann, Deborah Sultan and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024
    Review
  10. Review
  11. Molecular imaging of macrophage composition and dynamics in MASLD.JHEP reports : innovation in hepatology · 2024
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 1 country.

Xiuli ZhangMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Gyu Seong HeoMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Alexandria LiMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Divangana LahadMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Lisa DeteringMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Joan TaoDepartment of Medicine, University of Missouri, Columbia, Missouri.
Xuefeng GaoMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Xiaohui ZhangMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Hannah LuehmannMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Deborah SultanMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Lanlan LouMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Rajiu VenkatesanMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Ran LiMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Jie ZhengMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Junedh AmruteDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri; and.
Chieh-Yu LinDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri.
Benjamin J KopeckyDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri; and.
Robert J GroplerMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri.
Andrea BredemeyerDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri; and.
Kory LavineDepartment of Medicine, Washington University in St. Louis, St. Louis, Missouri; and.
Yongjian LiuMallinckrodt Institute of Radiology, University of Missouri, Columbia, Missouri; yongjianliu@wustl.edu.
Mallinckrodt (United States) · USUniversity of Missouri · USWashington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
Pediatric Cardiovascular and Pulmonary Research Training Program.T32HL125241 · NHLBI · WASHINGTON UNIVERSITY · PI Juliane Bubeck Wardenburg, Kory J. Lavine · 2015 to 2026
$4.1M
Molecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2021 to 2025
$3.7M
PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
ACQUISITION OF A PRE-CLINICAL SIMULTANEOUS PET/MR SCANNERS10OD018515 · OD · WASHINGTON UNIVERSITY · PI LAFOREST, RICHARD ANDRE · 2016 to 2016
$1.9M
Acquisition of high-resolution PET/CT preclinical imaging instrument at MIRS10OD030403 · OD · WASHINGTON UNIVERSITY · PI SHOGHI, KOORESH ISAAC · 2021 to 2021
$929k
Dissecting the Role of Donor CCR2- Macrophages During Acute Cellular Rejection After Heart TransplantationK08HL159359 · NHLBI · WASHINGTON UNIVERSITY · PI Benjamin J Kopecky · 2022 to 2026
$757k
NCI NIH HHS P30 CA091842NHLBI NIH HHS K08 HL159359NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R01 HL153436NHLBI NIH HHS R35 HL145212NHLBI NIH HHS R35 HL161185NHLBI NIH HHS T32 HL125241NIBIB NIH HHS P41 EB025815NIH HHS S10 OD018515NIH HHS S10 OD030403
6 · The paper itself

Abstract

Tissue-resident macrophages are complementary to proinflammatory macrophages to promote the progression of atherosclerosis. The noninvasive detection of their presence and dynamic variation will be important to the understanding of their role in the pathogenesis of atherosclerosis. The goal of this study was to develop a targeted PET radiotracer for imaging CD163-positive (CD163+) macrophages in multiple mouse atherosclerosis models and assess the potential of CD163 as a biomarker for atherosclerosis in humans.

Indexed as

Antigens, CDAntigens, Differentiation, MyelomonocyticAtherosclerosisMacrophagesPositron-Emission TomographyReceptors, Cell SurfaceAnimalsCD163 AntigenCopper RadioisotopesHumansMiceMice, Inbred C57BLRadiopharmaceuticalsTissue DistributionAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCopper RadioisotopesRadiopharmaceuticalsReceptors, Cell SurfaceatherosclerosisCD163PETresident macrophagestargeting

Identifiers

PMID38548349
PMCPMC11064833
OpenAlexW4393253292

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.