ArticleMicrobiome2024
The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model.
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Article in Microbiome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
9.9field-weighted citation impact, top 1% of its field
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- The role of ucOCN in aerobic exercise induced amelioration of autism spectrum disorder phenotypes.iScience · 2026Article
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- Gut microbiota-derived indole-3-propionic acid promotes lymph node metastasis in gastric cancer via the aryl-hydrocarbon receptor signaling pathway.Cancer & metabolism · 2026Article
- Enterococcus hirae QT4713-derived dopamine ameliorates intestinal inflammation and MPTP-induced Parkinson's disease in mice.NPJ Parkinson's disease · 2026Article
- Pre-treatment with baicalein alleviates the diquat-induced microglial pyroptosis through gut microbiota-derived indole-3-propionic acid and DDX3X/G3BP1 pathway.Cell biology and toxicology · 2026Article
- Microbiota-Gut-Brain Axis in Alzheimer's Disease: Linking Oxidative Stress, Mitochondrial Dysfunction and Amyloid Pathology-A Systematic Review.Biomedicines · 2026Review
- Gut-brain axis in health and brain disease.Chinese medical journal · 2026Review
- Molecular mechanisms and therapeutic potential of tryptophan metabolism in gut-brain signaling transduction: a narrative review.Journal of neuroinflammation · 2026Review
- Melatonin ameliorates autistic-like behaviors by restoring gut microbiota-derived tryptophan metabolites.Cellular and molecular life sciences : CMLS · 2026Article
- Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.Nature communications · 2026Article
- Exploring the therapeutic potential of the gut microbiota metabolite 3‑indolepropionic acid in parkinson's disease: a network pharmacology, molecular docking and cell viability study.Metabolic brain disease · 2026Article
- Melatonin Biosynthesis, Receptors, and the Microbiota-Tryptophan-Melatonin Axis: A Shared Dysbiosis Signature Across Cardiac Arrhythmias, Epilepsy, Malignant Proliferation, and Cognitive Trajectories.International journal of molecular sciences · 2026Article
- The Vitamin D-Gut-Brain Axis in Autism Spectrum Disorder: A Bidirectional Crosstalk.International journal of general medicine · 2026Review
- Do microbiota rhythms influence cognitive performance? - A narrative review.Frontiers in molecular neuroscience · 2026Review
- Microbial metabolites at the nexus of gut-brain communication and neurodevelopmental disorders.Frontiers in nutrition · 2026Review
- Gut Microbiota-driven Tryptophan Metabolism Towards the Indole Pathway MediatesInternational journal of biological sciences · 2026Article
- Metabolic crosstalk between intestinal microbiota and dendritic cells: from homeostasis to inflammation.Acta biochimica et biophysica Sinica · 2025Review
- Cntn4 Gene Deficiency Promotes Autism-Like Phenotypes Associated with Gut Microbiota Perturbations and Gut-Brain Axis Metabolomic Alterations in Mice.Molecular neurobiology · 2025Article
- Developmental exposure to methyl ester sulfonate induces autism-like behavioral deficits in mice by dysregulation of the Notch/Hes signaling pathway disrupting neuronal differentiation.Archives of toxicology · 2025Article
- Research progress of intestinal microbiota on cognitive dysfunction after spinal cord injury.iScience · 2025Review
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 3 countries.
Jian Jiang *Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Dilong Wang *Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Youheng Jiang *Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Xiuyan YangTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Runfeng SunInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Jinlong ChangTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Wenhui ZhuTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Peijia YaoTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Kun SongBrain Research Centre, Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Shuwen ChangThe Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen-Hong Kong Institute of Brain Science Shenzhen Fundamental Research Institutions, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Hong WangThe Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen-Hong Kong Institute of Brain Science Shenzhen Fundamental Research Institutions, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Lei ZhouInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Xue-Song ZhangCenter for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, NJ, USA. xuesong.zhang@rutgers.edu.
Huiliang LiWolfson Institute for Biomedical Research, Division of Medicine, Faculty of Medical Sciences, University College London, London, UK. huiliang.li@ucl.ac.uk.
Ningning LiTomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China. linn29@mail.sysu.edu.cn.
The Seventh Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CNHKUST Shenzhen Research Institute · CNShenzhen Bay Laboratory · CNAffiliated Hospital of Youjiang Medical University for Nationalities · CNRutgers, The State University of New Jersey · USSouthern University of Science and Technology · CNUniversity College London · GB
Funding
Hundred Talents Program of Sun Yat-sen University 392007, N.L.National Natural Science Foundation of China 81874176 and 82072766, N.L.Sanming Project of Medicine in Shenzhen SZSM201911003, N.L.Shenzhen Sanming Project of Medicine SZSM201911003, N.L.Shenzhen Science, Technology and Innovation Commission (SZSTI) Basic Research Program JCYJ20190809154411427, N.L.
Abstract
backgroundMicrodeletion of the human chromosomal region 16p11.2 (16p11.2
resultsMice with the 16p11.2
conclusionsOur study reveals that 16p11.2
Indexed as
Autism Spectrum DisorderPropionatesAnimalsHippocampusHumansIndolesMiceSynaptic TransmissionIndolesPropionatespropionic acidAutismGABAGut microbiota metaboliteIndole-3-propionic acidMapk3Social deficits
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.