Evidence map›Paper›PMID 38550978›Full record

ArticleiScience2024

High affinity mAb infusion can enhance maximum affinity maturation during HIV Env immunization.

Peter Thomas, Chloe Rees-Spear, Sarah Griffith, Luke Muir, Emma Touizer, Raiees Andrabi, Richard Priest, Jennifer Percival-Alwyn, Darryl Hayward, Amanda Buxton and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Modelling HIV-1 control and remission.NPJ systems biology and applications · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Peter ThomasInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Chloe Rees-SpearInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Sarah GriffithInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Luke MuirInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Emma TouizerInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Raiees AndrabiDepartment of Medicine, University of Pennsylvania, Philadelphia 19104, PA, USA.
Richard PriestBiopharmaceutical Molecular Discovery Group, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, UK.
Jennifer Percival-AlwynBiopharmaceutical Molecular Discovery Group, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, UK.
Darryl HaywardBiopharmaceutical Molecular Discovery Group, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, UK.
Amanda BuxtonIn vivo Sciences and Delivery, GSK, Park Road, Ware SG12 0DP, UK.
William TraylenIn vivo Sciences and Delivery, GSK, Park Road, Ware SG12 0DP, UK.
Benny ChainInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Trevor WattamBiopharmaceutical Molecular Discovery Group, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, UK.
Irene Sanjuan NandinImmunology Research Unit, GSK, Gunnels Wood Rd, Stevenage SG1 2NY, UK.
Laura E McCoyInstitute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London WC1E 6BT, UK.
Age UK · GBInstitute of Infection and Immunity · CAUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion. We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immunization regimen may progressively escalate selection pressure on competing B cells, increasing their affinity. To test this, we immunized mice with HIV envelope gp120 and infused CD4 binding-site (CD4bs)-specific mAbs. While mAb infusion reduced somatic hypermutation (SHM) and affinity in most CD4bs-specific B cells, a sub-population was identified with greater SHM and affinity than control. High-throughput sequencing of plasma cells revealed that CD4bs-specific plasma cells possessed elevated SHM after mAb infusion, with phylogenetic tree topology that suggested more rapid differentiation. We therefore conclude, in accordance with other studies, that high-affinity mAb infusion primarily suppresses recruitment of most competing B cells but can increase and expedite affinity maturation of certain epitope-specific B cells.

Indexed as

Immune responseImmunologyVirology

Identifiers

PMID38550978
PMCPMC10973984
OpenAlexW4392661717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.