Evidence map›Paper›PMID 38551485›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2024

Cardiac mitochondrial metabolism during pregnancy and the postpartum period.

Emily B Schulman-Geltzer, Kyle L Fulghum, Richa A Singhal, Bradford G Hill, Helen E Collins

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  2. Article
  3. From bump to pump: extracellular matrix remodeling, dynamics, and biomechanics in the maternal heart.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Review
  5. Maternal cardiovascular research and education should be prioritized in the United States.American journal of physiology. Heart and circulatory physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Emily B Schulman-GeltzerDivision of Environmental Medicine, Department of Medicine, Center for Cardiometabolic ScienceChristina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky, United States.ORCID 0009-0004-7893-0838
Kyle L FulghumDivision of Environmental Medicine, Department of Medicine, Center for Cardiometabolic ScienceChristina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky, United States.ORCID 0000-0003-0568-3544
Richa A SinghalDivision of Environmental Medicine, Department of Medicine, Center for Cardiometabolic ScienceChristina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky, United States.ORCID 0000-0002-8559-8798
Bradford G HillDivision of Environmental Medicine, Department of Medicine, Center for Cardiometabolic ScienceChristina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky, United States.
Helen E CollinsDivision of Environmental Medicine, Department of Medicine, Center for Cardiometabolic ScienceChristina Lee Brown Envirome Institute, University of Louisville, Louisville, Kentucky, United States.ORCID 0000-0002-9302-6044
University of Louisville · US

Funding

University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI Amanda Jo LeBlanc · 2020 to 2026
$10.0M
TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI JONES, STEVEN P · 2018 to 2022
$6.3M
Systematic identification of cardiotoxic e-cigarette flavorantsR01HL163818 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Alex Perrow Carll, Matthew A Nystoriak · 2022 to 2026
$3.8M
Biosynthetic Pathways in Cardiac RemodelingR01HL147844 · NHLBI · UNIVERSITY OF LOUISVILLE · PI HILL, BRADFORD GUY, JONES, STEVEN P · 2019 to 2022
$3.0M
Mechanisms Contributing to Pregnancy-induced Cardiac RemodelingR01HL163003 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Helen E Collins · 2023 to 2026
$2.1M
NHLBI NIH HHS R01 HL147844NHLBI NIH HHS R01 HL163003NHLBI NIH HHS R01 HL163818NIGMS NIH HHS P30 GM127607
6 · The paper itself

Abstract

The goal of the present study was to characterize changes in mitochondrial respiration in the maternal heart during pregnancy and after birth. Timed pregnancy studies were performed in 12-wk-old female FVB/NJ mice, and cardiac mitochondria were isolated from the following groups of mice: nonpregnant (NP), midpregnancy (MP), late pregnancy (LP), and 1-wk postbirth (PB). Similar to our previous studies, we observed increased heart size during all stages of pregnancy (e.g., MP and LP) and postbirth (e.g., PB) compared with NP mice. Differential cardiac gene and protein expression analyses revealed changes in several mitochondrial transcripts at LP and PB, including several mitochondrial complex subunits and members of the

Indexed as

Mitochondria, HeartPostpartum Period3-Hydroxybutyric AcidAnimalsCell RespirationEnergy MetabolismFemaleMiceOxygen ConsumptionPregnancyPyruvic Acid3-Hydroxybutyric AcidPyruvic Acidfemale cardiac biologyketone bodymitochondrial subunit complexesphysiological hypertrophysolute transporters

Identifiers

PMID38551485
PMCPMC11687956
OpenAlexW4393307637

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.