ArticleAging clinical and experimental research2024
Body composition parameters and sarcopenia in adults with Down syndrome: a case-control study.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Are Bioimpedance Parameters Altered in Adults With Down Syndrome? A Cross-Sectional Study.Journal of intellectual disability research : JIDR · 2026Article
- Nutrient Intake and Physical Activity of School-Aged Children with Trisomy 21 Living in Manitoba, Canada.Nutrients · 2026Article
- Aerobic Training for Obesity Management in Individuals with Down Syndrome: A Bibliometric and Meta-Analyses.Healthcare (Basel, Switzerland) · 2026Review
- TRISOMY 21: development of syndrome-specific growth charts from a wide Italian cohort and validation of BMI as a predictor of increased risk of metabolic derangement.Journal of endocrinological investigation · 2026Article
- Down Syndrome and Obesity Management: Lifestyle Observations Made in the Framework of the GO-DS21 Project and Clinical Recommendations.Nutrients · 2026Observational
- Pathophysiological Role of Vitamin D Deficiency in Down Syndrome: Insights into Metabolic Dysfunction and Sarcopenia.International journal of molecular sciences · 2025Review
- Probable sarcopenia and depressive symptoms in community-dwelling older adults: exploring the role of frailty and comorbidities.Aging clinical and experimental research · 2025Article
- A descriptive analysis of sarcopenia markers in young adults with down syndrome.Experimental gerontology · 2025Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with Down syndrome (DS) experience premature aging. Whether accelerated aging involves changes in body composition parameters and is associated with early development of sarcopenia is unclear.
aimsTo compare parameters of body composition and the prevalence of sarcopenia between adults with DS and the general population.
methodsBody composition was assessed by whole-body dual-energy X-ray absorptiometry (DXA). Fat mass (FMI) and skeletal mass indices (SMI) were calculated as the ratio between total body fat mass and appendicular lean mass and the square of height, respectively. Fat mass distribution was assessed by the android/gynoid fat ratio (A/G). Sarcopenia was defined according to the criteria and cut-points recommended by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). Data on age- and sex-matched non-DS controls were retrieved from the 2001-2002 National Health and Nutrition Examination Survey (NHANES) population.
resultsSixty-four DS adults (mean age 37.2 ± 12.0 years, 20.3% women) were enrolled and compared with age- and sex-matched NHANES participants (n = 256), in a 1:4 ratio. FMI (7.96 ± 3.18 kg/m
conclusionsAdults with DS have a higher prevalence of sarcopenia compared with the general population. This finding suggests that DS is associated with early muscle aging and calls for the design of interventions targeting the skeletal muscle to prevent or treat sarcopenia.
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