ArticleNature structural & molecular biology2024
Cryo-EM structures of amyloid-β and tau filaments in Down syndrome.
Open access · hybridAbstract read
In one paragraph
Article in Nature structural & molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Structural Hierarchy and Maturation of Amyloid Fibrils Revealed by Interface Descriptor Analysis.Journal of chemical information and modeling · 2026Article
- Distinct amyloid-β filament fold in individuals with APP Flemish mutation.Nature structural & molecular biology · 2026Article
- Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimer's Disease Brain.Nature communications · 2026Article
- Recent advances in Alzheimer's disease: From molecular mechanisms to therapeutic strategies.Cell · 2026Review
- Amyloid fibril polymorphism: Structural mechanisms of assembly and the links to disease.Current opinion in structural biology · 2026Review
- Brain-targeted delivery of siRNA via non-viral delivery systems, the therapeutic strategy for Alzheimer's disease-Unveiling challenges and prospects.International journal of pharmaceutics: X · 2026Review
- Use of anti-amyloid-β monoclonal antibodies in persons with Down syndrome Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Measurement of Tau Protein and Aβ Amyloid Plaques in Postmortem Human Brains of Down Syndrome and Alzheimer's Disease by Using [Synapse (New York, N.Y.) · 2026Article
- Unraveling Alzheimer's complexity with a distinct AβNature chemical biology · 2026Article
- Digging Deep into Alzheimer Disease: How Electron Microscopy Helps Elucidating Its Pathogenesis.Cellular and molecular neurobiology · 2026Review
- A Covalent Protein Painting Assay Differentiates Amyloid-β Polymorphs in Alzheimer Disease.Journal of proteome research · 2026Article
- Measurement of tau protein and Aβ amyloid plaques in postmortem human brains of Down syndrome and Alzheimer's disease by using [bioRxiv : the preprint server for biology · 2026Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- To What Extent is Anfinsen's Thermodynamic Hypothesis Consistent With the Formation and Polymorphism of Amyloid Fibrils?Journal of molecular biology · 2025Review
- Single-fibril Förster resonance energy transfer imaging and deep learning reveal concentration dependence of amyloid β 42 aggregation pathways.PNAS nexus · 2025Article
- Distinct Filament Conformation for Receptor-Bound Amyloid-ß from Alzheimer's Disease Brain.bioRxiv : the preprint server for biology · 2025Article
- Validation of helical symmetry parameters in the EMDB.Acta crystallographica. Section D, Structural biology · 2025Article
- Discordant cerebrospinal fluid and positron emission tomography amyloid biomarkers in an APP mutation carrier presenting corticobasal syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Employing deep mutational scanning in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cryo-EM of wild-type and mutant PMEL amyloid cores reveals structural mechanism of pigment dispersion syndrome.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Anllely Fernandez *Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Md Rejaul Hoq *Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.
Grace I Hallinan *Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Daoyi LiDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.
Sakshibeedu R BharathDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.
Frank S VagoDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.
Xiaoqi ZhangDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.
Kadir A OzcanDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0002-9337-9798
Kathy L NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Holly J GarringerDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1899-7676
Wen JiangDepartment of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, USA. jiang12@purdue.edu.ORCID http://orcid.org/0000-0002-1292-2411
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. bghetti@iupui.edu.ORCID http://orcid.org/0000-0002-1842-8019
Ruben VidalDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. rvidal@iupui.edu.ORCID http://orcid.org/0000-0002-5803-3871
Purdue University West Lafayette · USIndiana University School of Medicine
Funding
Atomic models of human tau filaments and development of tau ligandsU01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2018 to 2022
$3.5MIdentification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.R01AG080001 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, RUBEN VIDAL · 2023 to 2026
$2.7MStructural analysis of tau associated with parenchymal and vascular prion protein amyloidosisRF1AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2021 to 2021
$2.3MPurdue University Molecular Biophysics Training ProgramT32GM132024 · NIGMS · PURDUE UNIVERSITY · PI Angeline Marie Lyon, John Tesmer · 2019 to 2026
$2.0MCharacterization of the structural and molecular properties of propagating tau in vitro and in vivoK99AG078500 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI HALLINAN, GRACE ISABELLA · 2022 to 2023
$280kNIA NIH HHS K99 AG078500NIA NIH HHS R01 AG080001NIA NIH HHS RF1 AG071177NIGMS NIH HHS T32 GM132024NINDS NIH HHS U01 NS110437
Abstract
Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments from two DS brains. We found two Aβ
Indexed as
Amyloid beta-PeptidesCryoelectron MicroscopyDown Syndrometau ProteinsAdultAlzheimer DiseaseBrainHumansModels, MolecularPeptide FragmentsAmyloid beta-PeptidesPeptide Fragmentstau Proteins
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.