SynthesisPloS one2024
The biopsychosocial factors associated with development of chronic musculoskeletal pain. An umbrella review and meta-analysis of observational systematic reviews.
Synthesis in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- [The influence of diagnostic labels on treatment preferences of people with musculoskeletal pain : A systematic literature review].Schmerz (Berlin, Germany) · 2026Pooled it
- Comparative effectiveness of interventions incorporating physical activity in individuals with comorbid low back pain and depressive symptoms: a systematic review with network meta-analysis.Scientific reports · 2026Pooled it
- Association between passive smoking and oral health among children: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Musculoskeletal pain in adolescents: a systematic review of predictive and associated factors.BMC pediatrics · 2026Pooled it
- Psychological risk factors for lumbopelvic pain before, during, and after pregnancy: a systematic review.BMC pregnancy and childbirth · 2026Pooled it
- Prevention of sickness absence through early identification and rehabilitation of at-risk patients with musculoskeletal disorders (PREVSAM): 12-month follow-up of a randomised controlled trial.BMC musculoskeletal disorders · 2026Trial
- Mental Well-Being Is Associated With Temporomandibular Disorder Pain Onset and Remission.Journal of oral rehabilitation · 2026Article
- Development and Preliminary Evaluation of an AI-Assisted Clinical Decision Support System for Personalized Musculo-Skeletal Pain Management in Integrative Nursing Practice.Healthcare (Basel, Switzerland) · 2026Article
- Short-Term Effect of Negative Verbal Language Versus Positive Verbal Language on Physical and Functional Capacity and Pain in People With Chronic Primary Low Back Pain.European journal of pain (London, England) · 2026Article
- Exercise Participation and Clinical Characteristics of Desk-Based Workers with Chronic Non-Specific Neck Pain Exposed to Increased Ergonomic Risk: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Advancing Physical Therapy: Integrating Biomechanics, Neuroscience, and Systemic Health.Medicina (Kaunas, Lithuania) · 2026Article
- Dopamine transporter gene (Pain reports · 2026Article
- Novel Musculoskeletal Hypotheses in the Armed Services Trauma and Rehabilitation Outcome (ADVANCE) Cohort: Development and Application of Sparse Group Factor Analysis Methodology.Journal of medical Internet research · 2026Article
- Quality of Life in Adolescents with Idiopathic Scoliosis: A Longitudinal Study Exploring the Impact of Psychological Distress, Joint Hypermobility, Body Mass Index, and Physical Activity.Journal of clinical medicine · 2026Article
- Research Trends in Chronic Pain Physiotherapy: A Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2026Review
- Hypervigilance and kinesiophobia characterize distinct exploratory data-driven profiles of temporomandibular disorders.Scientific reports · 2026Observational
- Patients With Chronic Pain and Their Perspectives on Barriers and Opportunities for Earlier Opioid Tapering-A Qualitative Study Using Patient Journey Mapping.Musculoskeletal care · 2026Article
- The effect of Area Deprivation Index on clinical outcomes after total shoulder arthroplasty.Journal of shoulder and elbow arthroplasty · 2026Article
- Exploring the relationships between multisite musculoskeletal pain, pain characteristics, and physical function: a cross-sectional analysis.BMC musculoskeletal disorders · 2026Article
- Predicting the course of high-impact chronic pain using machine learning algorithms.The journal of pain · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this umbrella review was to establish which biopsychosocial factors are associated with development of chronic musculoskeletal pain.
methodsOvid Medline, Embase, Web of Science Core Collection, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, PsycINFO, CINAHL, PEDro, PROSPERO, Google Scholar and grey literature were searched from database inception to 4th April 2023. Systematic reviews of observational prospective longitudinal studies, including populations with <3 months (not chronic) musculoskeletal pain, investigating biopsychosocial factors that contribute to development of chronic (>3 months) musculoskeletal pain. Two reviewers searched the literature, assessed risk of bias (Assessing the Methodological Quality of Systematic Reviews-2), and evaluated quality (Grading of Recommendations, Assessment, Development and Evaluation) to provide an overall statement on the certainty of evidence for each biopsychosocial factor. Data analysis was performed through random effects meta-analysis (including meta-analysis of meta-analyses where possible) and descriptive synthesis.
results13 systematic reviews were included comprising 185 original research studies (n = 489,644 participants). Thirty-four biopsychosocial factors are associated with development of chronic musculoskeletal pain. Meta-analyses of odds and/or likelihood ratios were possible for 25 biopsychosocial factors. There is moderate certainty evidence that smoking (OR 1.24 [95%CI, 1.14-1.34), fear avoidance (LR+ 2.11 [95%CI, 1.59-2.8]; LR- 0.5 [95%CI, 0.35-0.71]) poorer support networks (OR 1.21 [95%CI, 1.14-1.29]), lower socioeconomic status (OR 2.0 [95%CI, 1.64-2.42]), and high levels of pain (OR 5.61 [95%CI, 3.74-8.43]) are associated with development of chronic musculoskeletal pain (all P<0.001). Remaining factors are of low or very low certainty evidence. CONCLUSIONS AND RELEVANCE: There is moderate certainty evidence that smoking, fear avoidance, poorer support networks, lower socioeconomic status, and high levels of pain are associated with development of chronic musculoskeletal pain. High risk of bias was evident in most included reviews; this highlights the need for higher quality systematic reviews.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.