Evidence map›Paper›PMID 38559065›Full record

ArticlebioRxiv : the preprint server for biology2024

Post-Translational Modifications Control Phase Transitions of Tau.

Wyatt C Powell, McKinley Nahum, Karl Pankratz, Morgane Herlory, James Greenwood, Darya Poliyenko, Patrick Holland, Ruiheng Jing, Luke Biggerstaff, Michael H B Stowell and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wyatt C PowellDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
McKinley NahumDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Karl PankratzDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Morgane HerloryDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
James GreenwoodDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Darya PoliyenkoDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Patrick HollandDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Ruiheng JingDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Luke BiggerstaffDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Michael H B StowellDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Maciej A WalczakDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID 0000-0002-8049-0817
University of Colorado Boulder · US

Funding

NCRR NIH HHS S10 RR028036NIA NIH HHS RF1 AG061829NIA NIH HHS RF1 AG079294
6 · The paper itself

Abstract

The self-assembly of Tau(297-391) into filaments, which mirror the structures observed in Alzheimer's disease (AD) brains, raises questions about the role of AD-specific post-translational modifications (PTMs) in the formation of paired helical filaments (PHFs). To investigate this, we developed a synthetic approach to produce Tau(291-391) featuring N-acetyllysine, phosphoserine, phosphotyrosine, and N-glycosylation at positions commonly modified in post-mortem AD brains, thus facilitating the study of their roles in Tau pathology. Using transmission electron microscopy (TEM), cryo-electron microscopy (cryo-EM), and a range of optical microscopy techniques, we discovered that these modifications generally hinder the

Identifiers

PMID38559065
PMCPMC10979912
OpenAlexW4392683316

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.