Evidence map›Paper›PMID 38559127›Full record

ArticlebioRxiv : the preprint server for biology2024

Genomic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats.

Christopher P King, Apurva S Chitre, Joel D Leal-Gutiérrez, Jordan A Tripi, Alesa R Hughson, Aidan P Horvath, Alexander C Lamparelli, Anthony George, Connor Martin, Celine L St Pierre and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 7 institutions in 1 country.

Christopher P KingDepartment of Psychology, University at Buffalo, Buffalo, USA.ORCID 0000-0002-6641-237X
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Joel D Leal-GutiérrezDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Jordan A TripiDepartment of Psychology, University at Buffalo, Buffalo, USA.
Alesa R HughsonDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Aidan P HorvathDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Alexander C LamparelliDepartment of Psychology, University at Buffalo, Buffalo, USA.
Anthony GeorgeClinical and Research Institute on Addictions, Buffalo, USA.
Connor MartinClinical and Research Institute on Addictions, Buffalo, USA.
Celine L St PierreDepartment of Genetics, Washington University Saint Louis, St. Louis, USA.ORCID 0000-0001-5465-6601
Thiago SanchesDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Hannah V BimschlegerDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Jianjun GaoDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Riyan ChengDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Khai-Minh NguyenDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Katie L HollDepartment of Physiology, Medical College of Wisconsin, Milwaukee, USA.
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, La Jolla, USA.
Keita IshiwariClinical and Research Institute on Addictions, Buffalo, USA.
Hao ChenDepartment of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, USA.
Leah C Solberg WoodsDepartment of Internal Medicine, Molecular Medicine, Center on Diabetes, Obesity and Metabolism, Wake Forest School of Medicine, Winston-Salem, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, USA.ORCID 0000-0003-3634-0747
Terry E RobinsonDepartment of Psychology, University of Michigan, Ann Arbor, USA.
Shelly B FlagelDepartment of Psychiatry, University of Michigan, Ann Arbor, USA.
Paul J MeyerDepartment of Psychology, University at Buffalo, Buffalo, USA.
University of California San Diego · USUniversity at Buffalo, State University of New York · USUniversity of Michigan · USMedical College of Wisconsin · USUniversity of Tennessee Health Science Center · USWake Forest University · USWashington University in St. Louis · US

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
RESEARCH TRAINING ON ALCOHOL ETIOLOGY AND TREATMENTT32AA007583 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Gregory G Homish, KENNETH E LEONARD · 2000 to 2026
$8.5M
Nicotine amplification of behavioral and neural responses to alcohol cuesR01AA024112 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MEYER, PAUL J · 2016 to 2020
$1.8M
NIAAA NIH HHS R01 AA024112NIAAA NIH HHS T32 AA007583NIDA NIH HHS P50 DA037844
6 · The paper itself

Abstract

Addiction vulnerability is associated with the tendency to attribute incentive salience to reward predictive cues; both addiction and the attribution of incentive salience are influenced by environmental and genetic factors. To characterize the genetic contributions to incentive salience attribution, we performed a genome-wide association study (GWAS) in a cohort of 1,645 genetically diverse heterogeneous stock (HS) rats. We tested HS rats in a Pavlovian conditioned approach task, in which we characterized the individual responses to food-associated stimuli ("cues"). Rats exhibited either cue-directed "sign-tracking" behavior or food-cup directed "goal-tracking" behavior. We then used the conditioned reinforcement procedure to determine whether rats would perform a novel operant response for unrewarded presentations of the cue. We found that these measures were moderately heritable (SNP heritability,

Identifiers

PMID38559127
PMCPMC10980002
OpenAlexW4392902249

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.