Evidence map›Paper›PMID 38559128›Full record

ArticlebioRxiv : the preprint server for biology2024

Contrast-enhanced ultrasound imaging detects anatomical and functional changes in rat cervical spine microvasculature with normal aging.

Jennifer N Harmon, Preeja Chandran, Abarajithan Chandrasekaran, Jeffrey E Hyde, Gustavo J Hernandez, May J Reed, Matthew F Bruce, Zin Z Khaing

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jennifer N HarmonDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.ORCID 0000-0002-9013-519X
Preeja ChandranDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.
Abarajithan ChandrasekaranDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.
Jeffrey E HydeDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.
Gustavo J HernandezDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.
May J ReedDepartment of Gerontology and Geriatric Medicine, University of Washington, Seattle, WA, USA.
Matthew F BruceApplied Physics Laboratory, University of Washington, Seattle, WA, USA.
Zin Z KhaingDepartment of Neurological Surgery, University of Washington, 1959 NE Pacific St., Seattle, WA, USA.
University of Washington · USUniversity of Washington Applied Physics Laboratory · US

Funding

Role of physical training and intraspinal hemodynamic changes in the recovery of forelimb function after cervical spinal cord injury in ratsR01NS121191 · NINDS · UNIVERSITY OF WASHINGTON · PI KHAING, ZIN Z · 2021 to 2025
$1.9M
Viable Microvessels for the Study of the Microvasculature in Alzheimer's DiseaseR21AG073676 · NIA · UNIVERSITY OF WASHINGTON · PI REED, MAY J · 2021 to 2022
$428k
Defining microvascular structure and function in the aged cervical spinal cordR03AG073929 · NIA · UNIVERSITY OF WASHINGTON · PI KHAING, ZIN Z · 2022 to 2023
$156k
Development of Contrast Enhanced Functional Ultrasound Imaging to Monitor Induced Neuroplasticity in Chronic Spinal Cord InjuryF32HD107806 · NICHD · UNIVERSITY OF WASHINGTON · PI HARMON, JENNIFER · 2022 to 2023
$142k
NIA NIH HHS R03 AG073929NIA NIH HHS R21 AG073676NICHD NIH HHS F32 HD107806NINDS NIH HHS R01 NS121191
6 · The paper itself

Abstract

Normal aging is associated with significant deleterious cerebrovascular changes; these have been implicated in disease pathogenesis and increased susceptibility to ischemic injury. While these changes are well documented in the brain, few studies have been conducted in the spinal cord. Here, we utilize specialized contrast-enhanced ultrasound (CEUS) imaging to investigate age-related changes in cervical spinal vascular anatomy and hemodynamics in male Fisher 344 rats, a common strain in aging research. Aged rats (24-26 mo., N=6) exhibited significant tortuosity in the anterior spinal artery and elevated vascular resistance compared to adults (4-6 mo., N=6; tortuosity index 2.20±0.15 vs 4.74±0.45, p<0.05). Baseline blood volume was lower in both larger vessels and the microcirculation in the aged cohort, specifically in white matter (4.44e14±1.37e13 vs 3.66e14±2.64e13 CEUS bolus AUC, p<0.05). To elucidate functional differences, animals were exposed to a hypoxia challenge; whereas adult rats exhibited significant functional hyperemia in both gray and white matter (GM: 1.13±0.10-fold change from normoxia, p<0.05; WM: 1.16±0.13, p<0.05), aged rats showed no response. Immunohistochemistry revealed reduced pericyte coverage and activated microglia behavior in aged rats, which may partially explain the lack of vascular response. This study provides the first

Indexed as

Cervical spinal cordhypoxiaperfusionpericytes

Identifiers

PMID38559128
PMCPMC10980054
OpenAlexW4392791679

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.