Evidence map›Paper›PMID 38560715›Full record

ReviewADMET & DMPK2024

Metal-organic frameworks: Drug delivery applications and future prospects.

Prachi Mhettar, Niraj Kale, Jidnyasa Pantwalawalkar, Sopan Nangare, Namdeo Jadhav

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ADMET & DMPK, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Prachi MhettarDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013 Maharashtra State, India.
Niraj KaleDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013 Maharashtra State, India.
Jidnyasa PantwalawalkarDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013 Maharashtra State, India.
Sopan NangareDepartment of Pharmaceutical Chemistry, H. R Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, Maharashtra State, India.
Namdeo JadhavDepartment of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur 416013 Maharashtra State, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Metal-organic frameworks (MOFs) have gained incredible consideration in the biomedical field due to their flexible structural configuration, tunable pore size and tailorable surface modification. These inherent characteristics of MOFs portray numerous merits as potential drug carriers, depicting improved drug loading, site-specific drug delivery, biocompatibility, biodegradability, etc. Review approach: The current review article sheds light on the synthesis and use of MOFs in drug delivery applications. In the beginning, a brief overview of the key components and efficient fabrication techniques for MOF synthesis, along with its characterization methods, have been presented. The MOFs-based formulations have been critically discussed. The application of the design of experiments (DoE) approach to optimize MOFs has been elucidated. The MOFs-based formulations, especially the application of stimuli-responsive MOFs for site-specific drug delivery, have been deciphered. Along with drug release kinetic models, several administration methods for MOFs have also been enunciated. Subsequently, MOFs as future potential drug carriers have been elaborated. Key results and conclusion: Recently, MOFs have emerged as versatile drug delivery carriers possessing customization potential and meeting the needs of spatio-temporal drug delivery. Researchers have devised several environment-friendly approaches for MOF construction and surface modification. Owing to stimuli-responsive potential, MOFs have demonstrated their prominent therapeutic efficacy via several routes of administration. The numerous benefits of MOFs would certainly open up a new vista for its novel drug delivery applications.

Indexed as

drug loadingformulation developmentstimuli-responsive

Identifiers

PMID38560715
PMCPMC10974818

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.