Evidence map›Paper›PMID 38561249›Full record

ArticlePhysiological reports2024

Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.

Wouter H van Megen, Teun J van Houtert, Caro Bos, Dorien J M Peters, Jeroen H F de Baaij, Joost G J Hoenderop

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wouter H van MegenDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-7786-4021
Teun J van HoutertDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Caro BosDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Dorien J M PetersDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Jeroen H F de BaaijDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Joost G J HoenderopDepartment of Medical Biosciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1816-8544
Radboud University Nijmegen · NLLeiden University Medical Center · NL

Funding

Radboud Institute for Molecular Life Sciences
6 · The paper itself

Abstract

Mutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid-filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca

Indexed as

Polycystic Kidney, Autosomal DominantAdenosine TriphosphateAnimalsConnexinsHumansKidneyMiceMice, KnockoutMutationNerve Tissue ProteinsTRPP Cation ChannelsWater-Electrolyte BalanceAdenosine TriphosphateConnexinsNerve Tissue ProteinsPanx1 protein, mouseTRPP Cation ChannelsADPKDcalciumkidneymagnesiumpannexin‐1

Identifiers

PMID38561249
PMCPMC10984814
OpenAlexW4394765378

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.